Sodium Bicarbonate

Sodium Bicarbonate

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Questions & Answers

Side Effects & Adverse Reactions

Solutions containing sodium ions should be used with great care, if at all, in patients with congestive heart failure, severe renal insufficiency and in clinical states in which there exists edema with sodium retention.

In patients with diminished renal function, administration of solutions containing sodium ions may result in sodium retention.

The intravenous administration of these solutions can cause fluid and/or solute overloading resulting in dilution of serum electrolyte concentrations, overhydration, congested states or pulmonary edema.

Extravascular infiltration should be avoided, see ADVERSE REACTIONS.

 

Legal Issues

There is currently no legal information available for this drug.

FDA Safety Alerts

There are currently no FDA safety alerts available for this drug.

Manufacturer Warnings

There is currently no manufacturer warning information available for this drug.

FDA Labeling Changes

There are currently no FDA labeling changes available for this drug.

Uses

Sodium Bicarbonate Injection, USP is indicated in the treatment of metabolic acidosis which may occur in severe renal disease, uncontrolled diabetes, circulatory insufficiency due to shock or severe dehydration, extracorporeal circulation of blood, cardiac arrest and severe primary lactic acidosis. Sodium bicarbonate is further indicated in the treatment of certain drug intoxications, including barbiturates (where dissociation of the barbiturate-protein complex is desired), in poisoning by salicylates or methyl alcohol and in hemolytic reactions requiring alkalinization of the urine to diminish nephrotoxicity of blood pigments. Sodium bicarbonate also is indicated in severe diarrhea which is often accompanied by a significant loss of bicarbonate.

Treatment of metabolic acidosis should, if possible, be superimposed on measures designed to control the basic cause of the acidosis ― e.g., insulin in uncomplicated diabetes, blood volume restoration in shock. But since an appreciable time interval may elapse before all of the ancillary effects are brought about, bicarbonate therapy is indicated to minimize risks inherent to the acidosis itself.

Vigorous bicarbonate therapy is required in any form of metabolic acidosis where a rapid increase in plasma total CO2 content is crucial ― e.g., cardiac arrest, circulatory insufficiency due to shock or severe dehydration, and in severe primary lactic acidosis or severe diabetic acidosis.

 

History

There is currently no drug history available for this drug.

Other Information

Sodium Bicarbonate Injection, USP is a sterile, nonpyrogenic, hypertonic solution of sodium bicarbonate (NaHCO3) in water for injection for administration by the intravenous route as an electrolyte replenisher and systemic alkalizer.

Solutions are offered in concentrations of 4.2%, 5.0%, 7.5% and 8.4%. See table in HOW SUPPLIED section for contents and characteristics.

Solution in LVP container has 0.9 mg/mL of edetate disodium, anhydrous added as a stabilizer.

The solutions contain no bacteriostat, antimicrobial agent or added buffer and are intended only for use as a single-dose injection. When smaller doses are required, the unused portion should be discarded with the entire unit.

Sodium bicarbonate, 84 mg is equal to one milliequivalent each of Na+ and HCO3¯. Sodium Bicarbonate, USP is chemically designated NaHCO3, a white crystalline powder soluble in water.

Water for Injection, USP is chemically designated H2O.

 

Sodium Bicarbonate Manufacturers


  • Remedyrepack Inc.
    Sodium Bicarbonate Injection, Solution [Remedyrepack Inc. ]
  • Mckesson Packaging Services Business Unit Of Mckesson Corporation
    Sodium Bicarbonate Injection, Solution [Mckesson Packaging Services Business Unit Of Mckesson Corporation]
  • General Injectables & Vaccines, Inc
    Sodium Bicarbonate Injection, Solution [General Injectables & Vaccines, Inc]
  • General Injectables & Vaccines, Inc
    Sodium Bicarbonate Injection, Solution [General Injectables & Vaccines, Inc]
  • Rugby Laboratories, Inc.
    Sodium Bicarbonate Tablet [Rugby Laboratories, Inc.]
  • Rugby Laboratories, Inc.
    Sodium Bicarbonate Tablet [Rugby Laboratories, Inc.]
  • General Injectables & Vaccines, Inc.
    Sodium Bicarbonate Injection [General Injectables & Vaccines, Inc.]
  • Mirror Pharmaceuticals Llc
    Sodium Bicarbonate Tablet [Mirror Pharmaceuticals Llc]
  • General Injectables & Vaccines, Inc
    Sodium Bicarbonate Injection, Solution [General Injectables & Vaccines, Inc]
  • General Injectables & Vaccines, Inc
    Sodium Bicarbonate Injection, Solution [General Injectables & Vaccines, Inc]
  • General Injectables & Vaccines, Inc
    Sodium Bicarbonate Injection, Solution [General Injectables & Vaccines, Inc]
  • Hospira, Inc.
    Sodium Bicarbonate Injection, Solution [Hospira, Inc.]
  • Rising Pharmaceuticals, Inc.
    Sodium Bicarbonate (Sodium Bicarbonate) Tablet, Orally Disintegrating [Rising Pharmaceuticals, Inc.]
  • Hospira, Inc.
    Sodium Bicarbonate Injection, Solution [Hospira, Inc.]
  • International Medication Systems, Limited
    Sodium Bicarbonate Injection [International Medication Systems, Limited ]
  • Cardinal Health
    Sodium Bicarbonate Injection, Solution [Cardinal Health]
  • Cardinal Health
    Sodium Bicarbonate Injection, Solution [Cardinal Health]
  • Cardinal Health
    Sodium Bicarbonate Injection, Solution [Cardinal Health]
  • Us Medsource, Llc
    Sodium Bicarbonate Injection, Solution [Us Medsource, Llc]
  • Hospira, Inc.
    Sodium Bicarbonate Injection, Solution [Hospira, Inc.]
  • Fresenius Kabi Usa, Llc
    Sodium Bicarbonate Injection, Solution [Fresenius Kabi Usa, Llc]
  • Cardinal Health
    Sodium Bicarbonate Tablet [Cardinal Health]
  • Cardinal Health
    Sodium Bicarbonate Injection, Solution [Cardinal Health]

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