Solu-delta-cortef
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SOLU-DELTA-CORTEF Sterile Powder contains prednisolone sodium succinate which is a salt of prednisolone that is particularly suitable for intravenous or intramuscular injection because it is highly water soluble, permitting administration of relatively large doses in a small volume of diluent. It is especially designed for intravenous use in situations requiring rapid and intense glucocorticoid and/or anti-inflammatory effect; however, it may be used by the intramuscular route in less acute conditions.
*Each mL (when mixed) of these preparations contains:
| 100 mg | 500 mg | |
|---|---|---|
| Prednisolone sodium succinate equivalent to prednisolone | 10 mg | 50 mg |
| Monobasic sodium phosphate anhydrous | 0.075 mg | 0.075 mg |
| Dibasic sodium phosphate dried | 0.81 mg | 0.81 mg |
| Lactose hydrous | 19.6 mg | 19.6 mg |
| Tyloxapol | 4.9 mg | 4.9 mg |
When necessary, pH was adjusted with sodium hydroxide and/or hydrochloric acid.
Metabolic and Hormonal Effects. Prednisolone, a derivative of hydrocortisone, has greater glucocorticoid activity, greater anti-inflammatory activity, less sodium-retaining effect, and less potassium-losing effect than the parent compound.
The glucocorticoid activity of prednisolone is approximately 4 times that of hydrocortisone and 5 times that of cortisone as measured in experimental animals in terms of liver glycogen deposition, eosinopenic response, and thymic involution.
The anti-inflammatory activity of prednisolone is at least 4 times that of hydrocortisone. SOLU-DELTA-CORTEF exerts an inhibitory influence on the cellular, fibrous, and amorphous components of connective tissue and thereby suppresses the basic processes of inflammation. Vascular permeability is decreased, exudation diminished, and the migration of inflammatory cells markedly impaired.
Sources
Solu-delta-cortef Manufacturers
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Zoetis Inc.
![Solu-delta-cortef (Prednisolone Sodium Succinate, Sodium Phosphate, Monobasic, Sodium Phosphate, Dibasic, And Lactose Monohydrate) Powder [Zoetis Inc.]](/wp-content/themes/bootstrap/assets/img/loading2.gif)
Solu-delta-cortef | Zoetis Inc.
Horses: The dosage for horses is 50 to 100 mg as an initial dose. This may be given intravenously over a period of ½ to 1 minute, or intramuscularly, and may be repeated in inflammatory, allergic, or other stress conditions, at intervals of 12, 24, or 48 hours, depending upon the size of the animal, the severity of the condition, and the response to treatment. When steroid therapy is to be more prolonged, as in a chronic arthritic condition, DEPO-MEDROL® Sterile Aqueous Suspension containing methylprednisolone or PREDEF® 2X Sterile Aqueous Suspension containing isoflupredone acetate may be injected intramuscularly and continued daily, depending on the severity of the condition and response to treatment.
Dogs: The usual intravenous dose in shock and shock-like states ranges from 2.5 to 5 mg per lb of body weight as an initial dose, followed by equal maintenance doses at 1-, 3-, 6-, or 10-hour intervals as determined by the condition of the patient.
Dogs and Cats: The intramuscular dose in inflammatory, allergic, and less severe stress conditions, where immediate effect is not required, is usually 1 to 5 mg ranging upwards to 30 to 50 mg in large breeds of dogs. This may be repeated in 12 to 24 hours and continued for 3 to 5 days, if necessary. When steroid therapy is to be more prolonged, as in a chronic arthritic or dermal condition, DEPO-MEDROL Sterile Aqueous Suspension may be used. If permanent corticosteroid effect is required, oral therapy with prednisolone tablets may be substituted as soon as possible. When therapy is to be withdrawn after prolonged corticosteroid administration, the daily dose should be reduced gradually over a number of days, in stepwise fashion.
Choice of appropriate concentration of SOLU-DELTA-CORTEF Sterile Powder will help minimize discard of unused drug. It is suggested that the 10 mg/mL formulation be used to treat cats and horses of any size as well as dogs weighing less than 40 pounds. For intravenous treatment of shock in dogs weighing over 40 pounds use the 50 mg/mL formulation. Do not use 50 mg/mL formulation in dogs and cats for intramuscular use.
All intravenous injections should be administered slowly.
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