2.1 Dosage in Adult Patients
The dose of moxifloxacin is 400 mg (orally) once every 24 hours. The duration of therapy depends on the type of infection as described in Table 1.
Table 1: Dosage and Duration of Therapy in Adult Patients
Type of Infectiona
Dose Every 24 hours
Durationb (days)
a) Due to the designated pathogens [see Indications and Usage (1), for IV use, see Use in Specific Populations (8.5)].
b) Sequential therapy (intravenous to oral) may be instituted at the discretion of the physician.
Acute Bacterial Sinusitis (1.1)
400 mg
10
Acute Bacterial Exacerbation of Chronic Bronchitis (1.2)
400 mg
5
Community Acquired Pneumonia
400 mg
7-14
Uncomplicated Skin and Skin Structure Infections (SSSI ) (1.4)
400 mg
7
Complicated SSSI (1.5)
400 mg
7-21
Complicated Intra-Abdominal Infections (1.6)
400 mg
5-14
Intravenous formulation is indicated when it offers a route of administration advantageous to the patient (for example, patient cannot tolerate an oral dosage form). When switching from intravenous to oral formulation, no dosage adjustment is necessary. Patients whose therapy is started with moxifloxacin hydrochloride IV may be switched to moxifloxacin hydrochloride tablets when clinically indicated at the discretion of the physician.
2.2 Drug Interactions with Multivalent Cations
Oral doses of moxifloxacin should be administered at least 4 hours before or 8 hours after products containing magnesium, aluminum, iron or zinc, including antacids, sucralfate, multivitamins and VIDEX® (didanosine) chewable/buffered tablets or the pediatric powder for oral solution [see Drug Interactions (7.1) and Clinical Pharmacology (12.3)].
2.3 Administration Instructions
Moxifloxacin hydrochloride tablets can be taken with or without food, drink fluids liberally.