Thyrotox
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Questions & Answers
Side Effects & Adverse Reactions
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Legal Issues
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FDA Safety Alerts
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Manufacturer Warnings
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FDA Labeling Changes
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Uses
Sildenafil injection is indicated for the treatment of pulmonary arterial hypertension (WHO Group I) in adults to improve exercise ability and delay clinical worsening. The delay in clinical worsening was demonstrated when sildenafil injection was added to background epoprostenol therapy [see Clinical Studies (14)].
Studies establishing effectiveness were short-term (12 to 16 weeks), and included predominately patients with New York Heart Association (NYHA) Functional Class II-III symptoms and idiopathic etiology (71%) or associated with connective tissue disease (CTD) (25%).
History
There is currently no drug history available for this drug.
Other Information
Sildenafil injection, phosphodiesterase-5 (PDE-5) inhibitor, is the citrate salt of sildenafil, a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type-5 (PDE-5). Sildenafil is also marketed as VIAGRA® for erectile dysfunction.
Sildenafil citrate is designated chemically as 1-[[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo [4,3-d] pyrimidin-5-yl)-4-ethoxyphenyl] sulfonyl]-4-methylpiperazine citrate and has the following structural formula:
Sildenafil citrate USP is a white or almost white slightly hygroscopic crystalline powder with a solubility of 3.5 mg/mL in water and a molecular weight of 666.7.
Sildenafil injection is supplied as a clear, colorless, sterile, ready to use solution in a single-use vial containing 10 mg/12.5 mL of sildenafil. Each mL of solution contains 1.124 mg sildenafil citrate USP equivalent to 0.8 mg sildenafil, 50.5 mg dextrose and water for injection.
Sources
Thyrotox Manufacturers
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Apotheca Company
![Thyrotox (Chondrus Crispus, Fucus Vesiculosus, Thyroidinum, Belladonna, Calcarea Carbonica, Conium Maculatum, Iodium, Kali Carbonicum. Phosphorus, Pulsatilla, Silicea,) Liquid [Apotheca Company]](/wp-content/themes/bootstrap/assets/img/loading2.gif)
Thyrotox | Auromedics Pharma Llc
2.2 Sildenafil InjectionSildenafil injection is for the continued treatment of patients with PAH who are currently prescribed oral sildenafil and who are temporarily unable to take oral medication.
The recommended dose is 10 mg administered as an intravenous bolus injection three times a day. The dose of sildenafil injection does not need to be adjusted for body weight.
A 10 mg dose of sildenafil injection is predicted to provide pharmacological effect of sildenafil and its N-desmethyl metabolite equivalent to that of a 20 mg oral dose. -
Bioactive Nutritional, Inc.
Thyrotox | Bioactive Nutritional, Inc.
10 drops orally, 3 times a day. Consult a physician for use in children under 12 years of age.
![Thyrotox (Chondrus Crispus, Fucus Vesiculosus, Thyroidinum, Belladonna, Calcarea Carbonica, Conium Maculatum) Liquid [Bioactive Nutritional, Inc.]](http://dailymed.nlm.nih.gov/dailymed/image.cfm?setid=e229a260-13f3-4136-b325-9a8954f8a327&name=X45THYROTOX.jpg)
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