Tolterodine Tartrate

Tolterodine Tartrate

Tolterodine Tartrate Recall

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Questions & Answers

Side Effects & Adverse Reactions

Anaphylaxis and angioedema requiring hospitalization and emergency medical treatment have occurred with the first or subsequent doses of tolterodine tartrate. In the event of difficulty in breathing, upper airway obstruction, or fall in blood pressure, tolterodine tartrate should be discontinued and appropriate therapy promptly provided.

Legal Issues

There is currently no legal information available for this drug.

FDA Safety Alerts

There are currently no FDA safety alerts available for this drug.

Manufacturer Warnings

There is currently no manufacturer warning information available for this drug.

FDA Labeling Changes

There are currently no FDA labeling changes available for this drug.

Uses

Tolterodine tartrate tablets are indicated for the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and frequency.

History

There is currently no drug history available for this drug.

Other Information

This product contains tolterodine tartrate. The active moiety, tolterodine, is a muscarinic receptor antagonist. The chemical name of tolterodine tartrate is (R)-2-[3-[bis(1-methylethyl)-amino]1-phenylpropyl]-4-methylphenol [R-(R*,R*)]-2,3-dihydroxybutanedioate (1:1) (salt). The empirical formula of tolterodine tartrate is C26H37NO7, and its molecular weight is 475.6. The structural formula of tolterodine tartrate is represented below:

tolterodine-tartrate

Tolterodine tartrate is a white, crystalline powder. The pKa value is 9.87 and the solubility in water is 12 mg/mL. It is soluble in methanol, slightly soluble in ethanol, and practically insoluble in toluene. The partition coefficient (Log D) between n-octanol and water is 1.83 at pH 7.3.

Tolterodine tartrate tablets for oral administration contain 1 or 2 mg of tolterodine tartrate. The inactive ingredients are colloidal silicon dioxide, dibasic calcium phosphate dihydrate, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, sodium starch glycolate and titanium dioxide.

Tolterodine Tartrate Manufacturers


  • Apotex Corp.
    Tolterodine Tartrate Tablet, Film Coated [Apotex Corp.]
  • Mylan Pharmaceuticals Inc.
    Tolterodine Tartrate (Tolterodine) Tablet, Film Coated [Mylan Pharmaceuticals Inc.]
  • Mylan Institutional Inc.
    Tolterodine Tartrate (Tolterodine) Tablet, Film Coated [Mylan Institutional Inc.]
  • Teva Pharmaceuticals Usa Inc
    Tolterodine Tartrate Tablet, Film Coated [Teva Pharmaceuticals Usa Inc]
  • Mylan Pharmaceuticals Inc.
    Tolterodine Tartrate Capsule, Extended Release [Mylan Pharmaceuticals Inc.]
  • Teva Pharmaceuticals Usa Inc
    Tolterodine Tartrate Capsule, Extended Release [Teva Pharmaceuticals Usa Inc]
  • Mylan Institutional Inc.
    Tolterodine Tartrate Capsule, Extended Release [Mylan Institutional Inc.]
  • Greenstone Llc
    Tolterodine Tartrate Tablet, Film Coated [Greenstone Llc]
  • Macleods Pharmaceuticals Limited
    Tolterodine Tartrate Tablet, Film Coated [Macleods Pharmaceuticals Limited]
  • Teva Pharmaceuticals Usa Inc
    Tolterodine Tartrate Tablet, Film Coated [Teva Pharmaceuticals Usa Inc]

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