Tramadol Hydrochloride

Tramadol Hydrochloride

Tramadol Hydrochloride Recall

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Questions & Answers

Side Effects & Adverse Reactions

There is currently no warning information available for this product. We apologize for any inconvenience.

Legal Issues

There is currently no legal information available for this drug.

FDA Safety Alerts

There are currently no FDA safety alerts available for this drug.

Manufacturer Warnings

There is currently no manufacturer warning information available for this drug.

FDA Labeling Changes

There are currently no FDA labeling changes available for this drug.

Uses

Tramadol Hydrochloride Extended-Release is indicated for the management of moderate to moderately severe chronic pain in adults who require around-the-clock treatment of their pain for an extended period of time.

History

There is currently no drug history available for this drug.

Other Information

Tramadol Hydrochloride Extended-Release (tramadol hydrochloride) capsules is a centrally acting synthetic analgesic in an extended-release oral formulation. The chemical name for tramadol hydrochloride is (±) cis-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl) cyclohexanol hydrochloride. Its structural formula is:

Figure 1

Structural Formula

The molecular weight of tramadol hydrochloride is 299.8. It is a white, bitter, crystalline and odorless powder that is readily soluble in water and ethanol and has a pKa of 9.41. The n-octanol/water log partition coefficient (logP) is 1.35 at pH 7. Tramadol Hydrochloride Extended-Release capsules contain a total dose of tramadol HCl 100, 200 and 300 mg in a combination of immediate-release and extended-release components.

DosageImmediate-releaseExtended-release
150 mg37.5 mg112.5 mg

Tramadol Hydrochloride Extended-Release capsules are white in color. Inactive ingredients include gelatin, titanium dioxide, shellac, yellow iron oxide, lactose monohydrate 200 mesh, microcrystalline cellulose, povidone K30, corn starch, sodium starch glycolate, magnesium stearate, sucrose stearate, hypromellose, talc, polysorbate 80, Eudragit NE 30D, and simethicone emulsion.

Tramadol Hydrochloride Manufacturers


  • Medsource Pharmaceuticals
    Tramadol Hydrochloride Capsule, Extended Release [Medsource Pharmaceuticals]
  • Remedyrepack Inc.
    Tramadol Hydrochloride Tablet, Film Coated [Remedyrepack Inc. ]
  • Virtus Pharmaceuticals
    Tramadol Hydrochloride Tablet [Virtus Pharmaceuticals]
  • Cardinal Health
    Tramadol Hydrochloride Tablet, Coated [Cardinal Health]
  • Preferred Pharmaceuticals, Inc.
    Tramadol Hydrochloride Tablet, Film Coated [Preferred Pharmaceuticals, Inc.]
  • Remedyrepack Inc.
    Tramadol Hydrochloride Tablet, Extended Release [Remedyrepack Inc. ]
  • American Health Packaging
    Tramadol Hydrochloride Tablet, Extended Release [American Health Packaging]
  • Direct Rx
    Tramadol Hydrochloride Tablet, Extended Release [Direct Rx]
  • Remedyrepack Inc.
    Tramadol Hydrochloride Tablet, Film Coated [Remedyrepack Inc. ]
  • A-s Medication Solutions Llc
    Tramadol Hydrochloride Capsule, Extended Release [A-s Medication Solutions Llc]
  • A-s Medication Solutions Llc
    Tramadol Hydrochloride Tablet, Extended Release [A-s Medication Solutions Llc]
  • A-s Medication Solutions Llc
    Tramadol Hydrochloride Tablet [A-s Medication Solutions Llc]
  • A-s Medication Solutions Llc
    Tramadol Hydrochloride Tablet [A-s Medication Solutions Llc]
  • Blenheim Pharmacal, Inc.
    Tramadol Hydrochloride Tablet [Blenheim Pharmacal, Inc.]
  • Direct Rx
    Tramadol Hydrochloride Tablet, Coated [Direct Rx]
  • Par Pharmaceutical Inc.
    Tramadol Hydrochloride Tablet, Extended Release [Par Pharmaceutical Inc.]
  • Preferred Pharmaceuticals, Inc.
    Tramadol Hydrochloride Tablet, Extended Release [Preferred Pharmaceuticals, Inc.]
  • St. Mary’s Medical Park Pharmacy
    Tramadol Hydrochloride Tablet [St. Mary’s Medical Park Pharmacy ]
  • Actavis
    Tramadol Hydrochloride Tablet [Actavis]
  • Blenheim Pharmacal, Inc.
    Tramadol Hydrochloride Tablet [Blenheim Pharmacal, Inc.]
  • Altura Pharmaceuticals, Inc.
    Tramadol Hydrochloride Tablet [Altura Pharmaceuticals, Inc.]
  • Rebel Distributors Corp.
    Tramadol Hydrochloride Tablet, Extended Release Tramadol Hydrochloride Tablet, Extended Release [Rebel Distributors Corp.]
  • Keltman Pharmaceuticals Inc.
    Tramadol Hydrochloride Tablet [Keltman Pharmaceuticals Inc.]
  • Contract Pharmacy Services-pa
    Tramadol Hydrochloride Tablet [Contract Pharmacy Services-pa]
  • Physicians Total Care, Inc.
    Tramadol Hydrochloride Tablet, Extended Release [Physicians Total Care, Inc.]
  • St. Marys Medical Park Pharmacy
    Tramadol Hydrochloride Tablet, Extended Release [St. Marys Medical Park Pharmacy]
  • Cadila Healthcare Limited
    Tramadol Hydrochloride Tablet, Film Coated [Cadila Healthcare Limited]
  • Rebel Distributors Corp.
    Tramadol Hydrochloride Tablet [Rebel Distributors Corp.]
  • Cardinal Health
    Tramadol Hydrochloride Tablet, Film Coated [Cardinal Health]
  • Remedyrepack Inc.
    Tramadol Hydrochloride (Tramadol Hydrochloride) Tablet [Remedyrepack Inc. ]
  • Dispensing Solutions, Inc.
    Tramadol Hydrochloride Tablet, Extended Release [Dispensing Solutions, Inc.]
  • Lake Erie Medical Dba Quality Care Products Llc
    Tramadol Hydrochloride Tablet [Lake Erie Medical Dba Quality Care Products Llc]
  • Remedyrepack Inc.
    Tramadol Hydrochloride Tablet [Remedyrepack Inc. ]
  • Stat Rx Usa Llc
    Tramadol Hydrochloride Tablet [Stat Rx Usa Llc]
  • Life Line Home Care Services, Inc.
    Tramadol Hydrochloride Tablet [Life Line Home Care Services, Inc.]
  • Unit Dose Services
    Tramadol Hydrochloride Tablet, Extended Release [Unit Dose Services]
  • Stat Rx Usa Llc
    Tramadol Hydrochloride Tablet [Stat Rx Usa Llc]
  • Aidarex Pharmaceuticals Llc
    Tramadol Hydrochloride Tablet, Coated [Aidarex Pharmaceuticals Llc]
  • Aidarex Pharmaceuticals Llc
    Tramadol Hydrochloride Tablet [Aidarex Pharmaceuticals Llc]
  • Bryant Ranch Prepack
    Tramadol Hydrochloride Tablet [Bryant Ranch Prepack]
  • H.j. Harkins Company, Inc.
    Tramadol Hydrochloride Capsule, Extended Release [H.j. Harkins Company, Inc.]
  • Cardinal Health
    Tramadol Hydrochloride Tablet, Coated [Cardinal Health]
  • Unit Dose Services
    Tramadol Hydrochloride Capsule, Extended Release [Unit Dose Services]
  • Cardinal Health
    Tramadol Hydrochloride Tablet [Cardinal Health]
  • Remedyrepack Inc.
    Tramadol Hydrochloride Tablet, Extended Release [Remedyrepack Inc. ]
  • Med-health Pharma, Llc
    Tramadol Hydrochloride Tablet [Med-health Pharma, Llc]
  • Remedyrepack Inc.
    Tramadol Hydrochloride Tablet, Film Coated [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Tramadol Hydrochloride Tablet, Coated [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Tramadol Hydrochloride Tablet, Film Coated [Remedyrepack Inc. ]
  • Northstar Rxllc
    Tramadol Hydrochloride Tablet [Northstar Rxllc]
  • Remedyrepack Inc.
    Tramadol Hydrochloride Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Tramadol Hydrochloride Tablet [Remedyrepack Inc. ]
  • Lake Erie Medical Dba Quality Care Products Llc
    Tramadol Hydrochloride Tablet, Extended Release [Lake Erie Medical Dba Quality Care Products Llc]
  • Apotheca, Inc
    Tramadol Hydrochloride Tablet [Apotheca, Inc]
  • Remedyrepack Inc.
    Tramadol Hydrochloride Tablet, Extended Release [Remedyrepack Inc. ]
  • Dispensing Solutions, Inc.
    Tramadol Hydrochloride Tablet [Dispensing Solutions, Inc.]
  • Major Pharmaceuticals
    Tramadol Hydrochloride Tablet [Major Pharmaceuticals]
  • Remedyrepack Inc.
    Tramadol Hydrochloride Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Tramadol Hydrochloride Tablet, Extended Release [Remedyrepack Inc. ]
  • Virtus Pharmaceuticals Llc
    Tramadol Hydrochloride Tablet, Film Coated [Virtus Pharmaceuticals Llc]
  • Physicians Total Care, Inc.
    Tramadol Hydrochloride Tablet, Coated [Physicians Total Care, Inc.]
  • Unit Dose Services
    Tramadol Hydrochloride Tablet, Coated [Unit Dose Services]
  • Readymeds
    Tramadol Hydrochloride Tablet, Coated [Readymeds]
  • Cardinal Health
    Tramadol Hydrochloride Tablet [Cardinal Health]
  • Bryant Ranch Prepack
    Tramadol Hydrochloride Tablet, Coated [Bryant Ranch Prepack]
  • Direct Rx
    Tramadol Hydrochloride Capsule, Coated, Extended Release [Direct Rx]
  • Mckesson Packaging Services A Business Unit Of Mckesson Corporation
    Tramadol Hydrochloride Tablet, Coated [Mckesson Packaging Services A Business Unit Of Mckesson Corporation]
  • Amneal Pharmaceuticals Of New York, Llc
    Tramadol Hydrochloride Tablet, Coated [Amneal Pharmaceuticals Of New York, Llc]
  • Mylan Pharmaceuticals Inc.
    Tramadol Hydrochloride Tablet, Film Coated [Mylan Pharmaceuticals Inc.]
  • Aphena Pharma Solutions – Tennessee, Llc
    Tramadol Hydrochloride Tablet, Coated [Aphena Pharma Solutions – Tennessee, Llc]
  • Zydus Pharmaceuticals (Usa) Inc.
    Tramadol Hydrochloride Tablet, Film Coated [Zydus Pharmaceuticals (Usa) Inc.]
  • Sun Pharma Global Fze
    Tramadol Hydrochloride Tablet, Extended Release [Sun Pharma Global Fze]
  • Sun Pharma Global Fze
    Tramadol Hydrochloride Tablet, Extended Release [Sun Pharma Global Fze]
  • Patriot Pharmaceuticals, Llc
    Tramadol Hydrochloride Tablet, Extended Release [Patriot Pharmaceuticals, Llc]
  • Pd-rx Pharmaceuticals, Inc.
    Tramadol Hydrochloride Tablet, Coated [Pd-rx Pharmaceuticals, Inc.]
  • Pd-rx Pharmaceuticals, Inc.
    Tramadol Hydrochloride Tablet, Coated [Pd-rx Pharmaceuticals, Inc.]
  • Apotex Corp.
    Tramadol Hydrochloride Tablet, Coated [Apotex Corp.]
  • Mckesson Contract Packaging
    Tramadol Hydrochloride Tablet, Film Coated [Mckesson Contract Packaging]
  • Lupin Pharmaceuticals, Inc.
    Tramadol Hydrochloride Tablet, Extended Release [Lupin Pharmaceuticals, Inc.]
  • Teva Pharmaceuticals Usa Inc
    Tramadol Hydrochloride Tablet, Film Coated [Teva Pharmaceuticals Usa Inc]
  • Mylan Institutional Inc.
    Tramadol Hydrochloride Tablet, Film Coated [Mylan Institutional Inc.]
  • Lupin Pharmaceuticals, Inc.
    Tramadol Hydrochloride Tablet, Extended Release [Lupin Pharmaceuticals, Inc.]
  • Bryant Ranch Prepack
    Tramadol Hydrochloride Tablet, Coated [Bryant Ranch Prepack]
  • Sun Pharmaceutical Industries, Inc.
    Tramadol Hydrochloride Tablet [Sun Pharmaceutical Industries, Inc.]
  • Proficient Rx Lp
    Tramadol Hydrochloride Tablet, Coated [Proficient Rx Lp]
  • Proficient Rx Lp
    Tramadol Hydrochloride Capsule, Extended Release [Proficient Rx Lp]
  • American Health Packaging
    Tramadol Hydrochloride Tablet, Coated [American Health Packaging]
  • Aurobindo Pharma Limited
    Tramadol Hydrochloride Tablet, Film Coated [Aurobindo Pharma Limited]
  • Kle 2, Inc.
    Tramadol Hydrochloride Capsule, Extended Release [Kle 2, Inc.]
  • Cardinal Health
    Tramadol Hydrochloride Tablet [Cardinal Health]
  • Lake Erie Medical Dba Quality Care Products Llc
    Tramadol Hydrochloride (Tramadol Hydrochloride) Tablet, Extended Release Tramadol Hydrochloride (Tramadol Hydrochloride) Tablet, Extended Release [Lake Erie Medical Dba Quality Care Products Llc]
  • Major Pharmaceuticals
    Tramadol Hydrochloride Tablet, Film Coated [Major Pharmaceuticals]
  • Preferred Pharmaceuticals, Inc.
    Tramadol Hydrochloride Tablet [Preferred Pharmaceuticals, Inc.]
  • Preferred Pharmaceuticals, Inc.
    Tramadol Hydrochloride Capsule, Extended Release [Preferred Pharmaceuticals, Inc.]
  • Lake Erie Medical Dba Quality Care Products Llc
    Tramadol Hydrochloride Tablet [Lake Erie Medical Dba Quality Care Products Llc]
  • Lake Erie Medical Dba Quality Care Products Llc
    Tramadol Hydrochloride Tablet, Extended Release [Lake Erie Medical Dba Quality Care Products Llc]
  • Cardinal Health
    Tramadol Hydrochloride Tablet, Film Coated [Cardinal Health]
  • Lake Erie Medical Dba Quality Care Products Llc
    Tramadol Hydrochloride Capsule, Extended Release [Lake Erie Medical Dba Quality Care Products Llc]
  • A-s Medication Solutions Llc
    Tramadol Hydrochloride Tablet [A-s Medication Solutions Llc]
  • A-s Medication Solutions Llc
    Tramadol Hydrochloride Capsule, Extended Release [A-s Medication Solutions Llc]
  • A-s Medication Solutions Llc
    Tramadol Hydrochloride Tablet, Extended Release [A-s Medication Solutions Llc]
  • A-s Medication Solutions Llc
    Tramadol Hydrochloride Tablet [A-s Medication Solutions Llc]
  • Direct Rx
    Tramadol Hydrochloride Tablet [Direct Rx]
  • Preferred Pharmaceuticals Inc.
    Tramadol Hydrochloride Capsule, Extended Release [Preferred Pharmaceuticals Inc.]
  • Direct Rx
    Tramadol Hydrochloride Capsule [Direct Rx]
  • Preferred Pharmaceuticals Inc.
    Tramadol Hydrochloride Tablet, Extended Release [Preferred Pharmaceuticals Inc.]
  • Macleods Pharmaceuticals Limited
    Tramadol Hydrochloride Tablet, Film Coated [Macleods Pharmaceuticals Limited]
  • Aurobindo Pharma Limited
    Tramadol Hydrochloride Tablet, Extended Release [Aurobindo Pharma Limited]

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