Travoprost Ophthalmic Solution 0.004%
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Questions & Answers
Side Effects & Adverse Reactions
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Legal Issues
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FDA Safety Alerts
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Manufacturer Warnings
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FDA Labeling Changes
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Uses
Travoprost Ophthalmic Solution USP, 0.004% is indicated for the reduction of elevated intraocular pressure in patients with open angle glaucoma or ocular hypertension.
History
There is currently no drug history available for this drug.
Other Information
- Travoprost is a synthetic prostaglandin F analogue. Its chemical name is [1 R-[1α( Z),2β(1 E,3 R*),3α,5α]]-7-[3,5Dihydroxy-2-[3-hydroxy-4-[3(trifluoromethyl)phenoxy]-1-butenyl]cyclopentyl]-5heptenoic acid, 1-methylethylester. It has a molecular formula of C 26H 35F 3O 6 and a molecular weight of 500.55. The chemical structure of travoprost is:
Travoprost is a clear, colorless to slightly yellow oil that is very soluble in acetonitrile, methanol, octanol, and chloroform. It is practically insoluble in water.
Travoprost Ophthalmic Solution 0.004% is supplied as sterile, buffered aqueous solution of travoprost with a pH of approximately 6.0 and an osmolality of approximately 290 mOsmol/kg.
Travoprost ophthalmic solution contains: Active: travoprost 0.04 mg/mL; Preservative: benzalkonium chloride 0.15 mg/mL; Inactives: boric acid, edetate disodium, mannitol, polyoxyl 40 hydrogenated castor oil, tromethamine, sodium hydroxide and/or hydrochloric acid (to adjust pH) and water for injection.
Sources
Travoprost Ophthalmic Solution 0.004% Manufacturers
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Par Pharmaceutical, Inc.
![Travoprost Ophthalmic Solution 0.004% (Travoprost) Solution [Par Pharmaceutical, Inc.]](/wp-content/themes/bootstrap/assets/img/loading2.gif)
Travoprost Ophthalmic Solution 0.004% | Par Pharmaceutical, Inc.
The recommended dosage is one drop in the affected eye(s) once daily in the evening. Travoprost Ophthalmic Solution USP, 0.004% should not be administered more than once daily since it has been shown that more frequent administration of prostaglandin analogs may decrease the intraocular pressure lowering effect.
Reduction of the intraocular pressure starts approximately 2 hours after the first administration with maximum effect reached after 12 hours.
Travoprost ophthalmic solution may be used concomitantly with other topical ophthalmic drug products to lower intraocular pressure. If more than one topical ophthalmic drug is being used, the drugs should be administered at least five (5) minutes apart.
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