Trimethobenzamide Hydrochloride

Trimethobenzamide Hydrochloride

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Questions & Answers

Side Effects & Adverse Reactions

Caution should be exercised when administering trimethobenzamide hydrochloride capsules to children for the treatment of vomiting. Antiemetics are not recommended for treatment of uncomplicated vomiting in children and their use should be limited to prolonged vomiting of known etiology. There are two principal reasons for caution:

  1. The extrapyramidal symptoms which can occur secondary to trimethobenzamide hydrochloride capsules may be confused with the central nervous system signs of an undiagnosed primary disease responsible for the vomiting, e.g., Reye's syndrome or other encephalopathy.
  2. It has been suspected that drugs with hepatotoxic potential, such as trimethobenzamide hydrochloride capsules, may unfavorably alter the course of Reye's syndrome. Such drugs should therefore be avoided in children whose signs and symptoms (vomiting) could represent Reye's syndrome.

Trimethobenzamide hydrochloride capsules may produce drowsiness. Patients should not operate motor vehicles or other dangerous machinery until their individual responses have been determined.

Usage in Pregnancy

Trimethobenzamide hydrochloride was studied in reproduction experiments in rats and rabbits and no teratogenicity was suggested. The only effects observed were an increased percentage of embryonic resorptions or stillborn pups in rats administered 20 mg and 100 mg/kg and increased resorptions in rabbits receiving 100 mg/kg. In each study these adverse effects were attributed to one or two dams. The relevance to humans is not known. Since there is no adequate experience in pregnant or lactating women who have received this drug, safety in pregnancy or in nursing mothers has not been established.

Usage with Alcohol

Concomitant use of alcohol with trimethobenzamide hydrochloride capsules may result in an adverse drug interaction.

Legal Issues

There is currently no legal information available for this drug.

FDA Safety Alerts

There are currently no FDA safety alerts available for this drug.

Manufacturer Warnings

There is currently no manufacturer warning information available for this drug.

FDA Labeling Changes

There are currently no FDA labeling changes available for this drug.


Trimethobenzamide hydrochloride capsules are indicated for the treatment of postoperative nausea and vomiting and for nausea associated with gastroenteritis.


There is currently no drug history available for this drug.

Other Information

Chemically, trimethobenzamide HCl is N-[p-[2-(dimethylamino)ethoxy]benzyl]-3,4,5-trimethoxybenzamide monohydrochloride. It has a molecular weight of 424.93 and the following structural formula:

Chemical Structure

Each capsule for oral use contains trimethobenzamide hydrochloride equivalent to 300 mg.

Inactive Ingredients: FDA/E172 Red Iron Oxide, gelatin, magnesium stearate, microcrystalline cellulose, sodium starch glycolate and titanium dioxide. The imprinting ink contains D&C Yellow #10 Lake, FD&C Blue #1, FD&C Blue #2, FD&C Red #40, Iron Oxide Black, propylene glycol and shellac glaze.

Trimethobenzamide Hydrochloride Manufacturers

  • Rebel Distributors Corp.
    Trimethobenzamide Hydrochloride (Trimethobenzamide) Capsule [Rebel Distributors Corp.]
  • Lake Erie Medical Dba Quality Care Products Llc
    Trimethobenzamide Hydrochloride Capsule [Lake Erie Medical Dba Quality Care Products Llc]
  • General Injectables & Vaccines, Inc
    Trimethobenzamide Hydrochloride Injection, Solution [General Injectables & Vaccines, Inc]
  • Physicians Total Care, Inc.
    Trimethobenzamide Hydrochloride Capsule [Physicians Total Care, Inc.]
  • Mutual Pharmaceutical Company, Inc.
    Trimethobenzamide Hydrochloride Capsule [Mutual Pharmaceutical Company, Inc.]
  • Remedyrepack Inc.
    Trimethobenzamide Hydrochloride Capsule [Remedyrepack Inc. ]
  • Jhp Pharmaceuticals, Llc
    Trimethobenzamide Hydrochloride Injection [Jhp Pharmaceuticals, Llc]
  • Remedyrepack Inc.
    Trimethobenzamide Hydrochloride Capsule [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Trimethobenzamide Hydrochloride Capsule [Remedyrepack Inc. ]
  • Gavis Pharmaceuticals, Llc
    Trimethobenzamide Hydrochloride Capsule [Gavis Pharmaceuticals, Llc]
  • Remedyrepack Inc.
    Trimethobenzamide Hydrochloride Capsule [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Trimethobenzamide Hydrochloride Injection [Remedyrepack Inc. ]
  • Bryant Ranch Prepack
    Trimethobenzamide Hydrochloride Capsule [Bryant Ranch Prepack]

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