Zeel

Zeel Manufacturers

• Hameln Pharma Gmbh
  

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  Zeel | Hameln Pharma Gmbh

  

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  The dosage schedule listed below can be used as a general guide for the administration of Zeel® Injection Solution. Zeel® Injection Solution shows individual differences in clinical response. Therefore, the dosage for each patient should be individualized according to the patient's response to therapy.
  

  Adults and children 7 years and older: 1 ampule daily for acute disorders, or 1 ampule 1 to 3 times per week. Children ages 2 to 6 receive: ½ the adult dosage.

  Discard unused solution.
  
  Zeel® Injection Solution may be administered intravenously, intramuscularly, subcutaneously, or intradermally. The required dose of Zeel® Injection Solution is first withdrawn from the ampule into the syringe, and the syringe is then shaken briefly. Zeel® Injection Solution should be administered using a narrow gauge needle (e.g. 22 to 30 gauge). Note: Parental drug products like Zeel® Injection Solution should be inspected visually for particulate matter and discoloration prior to administration whenever solution and container permit. Zeel® Injection Solution is a clear, colorless solution.
  
  Discolored solutions should be discarded.
  

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• Heel Inc
  

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  Zeel | Heel Inc

  

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  Direction for use: Adults: Apply in the morning and evening to the effected areas, rubbing in gently. If appropriate, also apply an ointment dressing. Children under 18 years of age see a doctor.
  

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• Heel Inc
  

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  Zeel | Heel Inc

  

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  Direction for use: Adults: Apply in the morning and evening to the effected areas, rubbing in gently. If appropriate, also apply an ointment dressing. Children under 18 years of age see a doctor.
  

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• Biologische Heilmittel Heel
  

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  Zeel | Biologische Heilmittel Heel

  

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  Direction for use: Adults: Apply in the morning and evening to the effected areas, rubbing in gently. If appropriate, also apply an ointment dressing. Children under 18 years of age see a doctor.
  

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• Heel Inc
  

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  Zeel | Cardinal Health

  

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  There is considerable variation from patient to patient in the amount of medication required for treatment. As with all antipsychotic drugs, dosage should be individualized according to the needs and response of each patient. Dosage adjustments, either upward or downward, should be carried out as rapidly as practicable to achieve optimum therapeutic control.

  To determine the initial dosage, consideration should be given to the patient’s age, severity of illness, previous response to other antipsychotic drugs, and any concomitant medication or disease state. Children, debilitated or geriatric patients, as well as those with a history of adverse reactions to antipsychotic drugs, may require less haloperidol. The optimal response in such patients is usually obtained with more gradual dosage adjustments and at lower dosage levels, as recommended below.

  Clinical experience suggests the following recommendations:

  Oral Administration Inital Dosage Range Adults

  Moderate Symptomatology - 0.5 mg to 2 mg b.i.d. or t.i.d.

  Severe Symptomatology - 3 mg to 5 mg b.i.d. or t.i.d.

  Children

  The following recommendations apply to children between the ages of 3 and 12 years (weight range 15 kg to 40 kg). Haloperidol is not intended for children under 3 years old. Therapy should begin at the lowest dose possible (0.5 mg per day). If required, the dose should be increased by an increment of 0.5 mg at 5 to 7 day intervals until the desired therapeutic effect is obtained. (See chart below.)

  The total dose may be divided, to be given b.i.d. or t.i.d.

  Psychotic Disorders - 0.05 mg/kg/day to 0.15 mg/kg/day

  Nonpsychotic Behavior Disorders and Tourette's Disorder - 0.05 mg/kg/day to 0.075 mg/kg/day

  Severely disturbed psychotic children may require higher doses. In severely disturbed, non-psychotic children or in hyperactive children with accompanying conduct disorders, who have failed to respond to psychotherapy or medications other than antipsychotics, it should be noted that since these behaviors may be short lived, short term administration of haloperidol may suffice. There is no evidence establishing a maximum effective dosage. There is little evidence that behavior improvement is further enhanced in dosages beyond 6 mg per day.

  Maintenance Dosage

  Upon achieving a satisfactory therapeutic response, dosage should then be gradually reduced to the lowest effective maintenance level.

  Switchover Procedure

  The oral form should supplant the injectable as soon as practicable. In the absence of bioavailability studies establishing bioequivalence between these two dosage forms the following guidelines for dosage are suggested. For an initial approximation of the total daily dose required, the parenteral dose administered in the preceding 24 hours may be used. Since this dose is only an initial estimate, it is recommended that careful monitoring of clinical signs and symptoms, including clinical efficacy, sedation, and adverse effects, be carried out periodically for the first several days following the initiation of switchover. In this way, dosage adjustments, either upward or downward, can be quickly accomplished. Depending on the patient’s clinical status, the first oral dose should be given within 12 to 24 hours following the last parenteral dose.

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