Zetamine
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Questions & Answers
Side Effects & Adverse Reactions
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FDA Safety Alerts
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Manufacturer Warnings
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FDA Labeling Changes
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Uses
ZetamineTM (ketamine hydrochloride injection, USP) may be used in cats for restraint or as the sole anesthetic agent for diagnostic or minor, brief, surgical procedures that do not require skeletal muscle relaxation. It may be used in subhuman primates for restraint.
History
There is currently no drug history available for this drug.
Other Information
Ketamine hydrochloride is a rapid-acting, nonnarcotic, nonbarbiturate agent for anesthetic use in cats and for restraint in subhuman primates. It is chemically designated DL 2-(o-chlorophenyl) - 2 - (methylamino) cyclohexanone hydrochloride and is supplied as a slightly acid (pH 3.5 to 5.5) solution for intramuscular injection in a concentration containing the equivalent of 100 mg ketamine base per milliliter and contains 0.1 mg/mL benzethonium chloride as a preservative.
Sources
Zetamine Manufacturers
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Vetone
![Zetamine (Ketamine Hydrochloride) Injection, Solution [Vetone]](/wp-content/themes/bootstrap/assets/img/loading2.gif)
Zetamine | Vetone
Ketamine hydrochloride is well tolerated by cats and subhuman primates when administered by intramuscular injection.
Fasting prior to induction of anesthesia or restraint with ketamine hydrochloride is not essential; however, when preparing for elective surgery, it is advisable to withhold food for at least six hours prior to administration of ketamine hydrochloride.
Anesthesia may be of shorter duration in immature cats. Restraint in subhuman primate neonates (less than 24 hours of age) is difficult to achieve.
As with other anesthetic agents, the individual response to ketamine hydrochloride is somewhat varied depending upon the dose, general condition, and age of the subject so that dosage recommendations cannot be absolutely fixed.
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Mwi/vetone
Zetamine | Mwi/vetone
Zetamine™ is well tolerated by cats and subhuman primates when administered by intramuscular injection.
Fasting prior to induction of anesthesia or restraint with Zetamine™ is not essential; however, when preparing for elective surgery, it is advisable to withhold food for at least six hours prior to administration of Zetamine™.
Anesthesia may be of shorter duration in immature cats. Restraint in subhuman primate neonates (less than 24 hours of age) is difficult to achieve.
As with other anesthetic agents, the individual response to Zetamine™ is somewhat varied depending upon the dose, general condition and age of the subject so that dosage recommendations cannot be absolutely fixed.
A dose of 11 mg/kg (5 mg/lb) is recommended to produce restraint. Dosages from 22 to 33 mg/kg (10 to 15 mg/lb) produce anesthesia that is suitable for diagnostic or minor surgical procedures that do not require skeletal muscle relaxation.
The recommended restraint dosages of Zetamine™ (ketamine hydrochloride injection, USP) for the following species are: Cercocebus torquatus (white-collared mangabey), Papio cynocephalus (yellow baboon), Pan troglodytes verus (chimpanzee), Papio anubis (olive baboon), Pongo pygmaeus (orangutan), Macaca nemestrina (pig-tailed macaque) 5 to 7.5 mg/kg; Presbytis entellus (entellus langur) 3 to 5 mg/kg; Gorilla gorilla gorilla (gorilla) 7 to 10 mg/kg; Aotus trivirgatus (night monkey) 10 to 12 mg/kg; Macaca mulatta (rhesus monkey) 5 to 10 mg/kg; Cebus capucinus (white-throated capuchin) 13 to 15 mg/kg; and Macaca fascicularis (crab-eating macaque), Macaca radiata (bonnet macaque) and Saimiri sciureus (squirrel monkey) 12 to 15 mg/kg.
A single intramuscular injection produces restraint suitable for TB testing; radiography, physical examination or blood collection.
![Zetamine (Ketamine Hydrochloride) Injection [Mwi/vetone]](http://dailymed.nlm.nih.gov/dailymed/image.cfm?setid=2bcab3bd-78bc-4407-a057-0f21b80fb514&name=2bcab3bd-78bc-4407-a057-0f21b80fb514-01.jpg)
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