Zithranol-rr
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Questions & Answers
Side Effects & Adverse Reactions
WARNINGS
Avoid contact with the eyes or mucous membranes. Exercise care when applying Zithranol-RR cream to the face or intertriginous skin areas. Discontinue use if a sensitivity reaction occurs or if excessive irritation develops.
Legal Issues
There is currently no legal information available for this drug.
FDA Safety Alerts
There are currently no FDA safety alerts available for this drug.
Manufacturer Warnings
There is currently no manufacturer warning information available for this drug.
FDA Labeling Changes
There are currently no FDA labeling changes available for this drug.
Uses
INDICATIONS AND USAGE
For the topical treatment of patients with stable plaque psoriasis.
History
There is currently no drug history available for this drug.
Other Information
DESCRIPTION
Zithranol-RR contains 1.2% microcrystalline encapsulated anthralin in a green aqueous cream base containing glyceryl monolaurate, glyceryl monomyristate, citric acid, sodium hydroxide, FD&C Blue No. 1 and purified water. The anthralin in Zithranol-RR is microencapsulated into a proprietary formulation of surface active crystalline polar lipids to provide for rapid release, as well as to reduce irritation and staining frequently observed with nonencapsulated anthralin preparations. Since the monoglycerides comprising the microcrystalline matrix have significant antimicrobial properties, Zithranol-RR is resistant to microbial contamination or overgrowth without the need for a preservative agent. The chemical name of anthralin is 1,8-dihydroxy-9-anthrone and its structural formula is:
Sources
Zithranol-rr Manufacturers
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Elorac Inc.
![Zithranol-rr (Anthralin) Cream [Elorac Inc.]](/wp-content/themes/bootstrap/assets/img/loading2.gif)
Zithranol-rr | Elorac Inc.
DOSAGE AND ADMINISTRATIONGenerally, it is recommended that Zithranol-RR cream be applied once a day. Anthralin is known to be a potential skin irritant. The irritant potential of anthralin is directly related to the strength being used, the time of contact, and each patient’s individual tolerance. Where the response to anthralin treatment has not previously been established, commence treatment using a short contact time (5 – 15 min.) for at least one week. When a short contact time is used initially, it can be increased stepwise to thirty minutes before removing the cream by washing or showering. The optimal period of contact will vary according to the patient’s response to treatment.
For the skin: Apply sparingly to the psoriatic lesions avoiding normal skin and rub gently and carefully into the skin. Avoid applying an excessive quantity which may cause unnecessary soiling and staining of the clothing and/or bed linen. At the end of each period of treatment, rinse the skin thoroughly with cool to lukewarm water before washing with soap. The margins of the lesions may gradually become stained purple/brown as treatment progresses, but this will disappear after cessation of treatment.
For the scalp: Wash the hair with shampoo, rinse with water and apply Zithranol-RR cream while the hair is still damp. Rub the cream well into the psoriatic lesions. Keep Zithranol-RR cream away from the eyes. Care should be taken to avoid application to uninvolved scalp margins. Remove any unintended residue which may be deposited behind the ears. At the end of each period of contact, rinse hair and scalp thoroughly with cool to lukewarm water and then shampoo the hair and scalp to remove any surplus cream. This treatment may be repeated on alternate days if necessary.
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