On very rare occasions, the first dose of carisoprodol has been followed by an idiosyncratic reaction with symptoms appearing within minutes or hours. These may include extreme weakness, transient quadriplegia, dizziness, ataxia, temporary loss of vision, diplopia, mydriasis, dysarthia, agitation, euphoria, confusion and disorientation. Although symptoms usually subside over the course of the next several hours, discontinue Carisoprodol and Aspirin Tablets and initiate appropriate supportive and symptomatic therapy which may include epinephrine and/or antihistamines. In severe cases, corticosteriods may be necessary. Severe reactions have been manifested by asthmatic episodes, fever, weakness, dizziness angioneurotic edema, smarting eyes, hypotension and anaphylactoid shock.
The effects of carisoprodol with agents such as alcohol, other CNS depressants, or psychotropic drugs may be additive. Appropriate caution should be exercised with patients who may take one or more of these agents simultaneously with Carisoprodol and Aspirin Tablets.
There is currently no manufacturer warning information available for this drug.
Carisoprodol and Aspirin Tablets are indicated as an adjunct to rest, physical therapy, and other measures for the relief of pain, muscle spasm, and limited mobility associated with acute, painful musculoskeletal conditions.
This is a combination product containing Carisoprodol, a centrally-acting muscle relaxant, plus aspirin, an analgesic with antipyretic and anti-inflammatory properties. It is available as a two layered, white and light lavender round tablet for oral administration. Chemically, Carisoprodol is N-isopropyl-2-methyl-2-propyl-1, 3-propanediol dicarbamate. Its empirical formula is C12H24N2O4, with a molecular weight of 260.33. The structural formula is:
Chemically, aspirin is benzoic acid, 2-(acetyloxy)-. Its empirical formula is C9H8O4 with a molecular weight of 180.16. The structural formula is:
Each tablet for oral administration contains Carisoprodol 200 mg and Aspirin 325 mg.
Each tablet contains the following inactive ingredients: colloidal silicon dioxide, croscarmellose sodium, D&C Red #30, FD&C Blue #1, magnesium stearate, microcrystalline cellulose, povidone, starch, stearic acid and other ingredients.
