Hydrochlorothiazide

Hydrochlorothiazide

Hydrochlorothiazide Recall

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Questions & Answers

Side Effects & Adverse Reactions

Acute Myopia and Secondary Angle-Closure Glaucoma: Hydrochlorothiazide, a sulfonamide, can cause an idiosyncratic reaction, resulting in acute transient myopia and acute angle-closure glaucoma. Symptoms include acute onset of decreased visual acuity or ocular pain and typically occur within hours to weeks of drug initiation.  Untreated acute angle-closure glaucoma can lead to permanent vision loss.  The primary treatment is to discontinue hydrochlorothiazide as rapidly as possible.  Prompt medical or surgical treatments may need to be considered if the intraocular pressure remains uncontrolled.  Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy.

Diabetes and Hypoglycemia: Latent diabetes mellitus may become manifest and diabetic patients given thiazides may require adjustment of their insulin dose.

Renal Disease: Cumulative effects of the thiazides may develop in patients with impaired renal function. In such patients, thiazides may precipitate azotemia.

 

Legal Issues

There is currently no legal information available for this drug.

FDA Safety Alerts

There are currently no FDA safety alerts available for this drug.

Manufacturer Warnings

There is currently no manufacturer warning information available for this drug.

FDA Labeling Changes

There are currently no FDA labeling changes available for this drug.

Uses

Hydrochlorothiazide capsules are indicated in the management of hypertension either as the sole therapeutic agent, or in combination with other antihypertensives. Unlike potassium sparing combination diuretic products, hydrochlorothiazide capsules may be used in those patients in whom the development of hyperkalemia cannot be risked, including patients taking ACE inhibitors.

Usage in Pregnancy: The routine use of diuretics in an otherwise healthy woman is inappropriate and exposes mother and fetus to unnecessary hazard. Diuretics do not prevent development of toxemia of pregnancy, and there is no satisfactory evidence that they are useful in the treatment of developed toxemia.

Edema during pregnancy may arise from pathological causes or from the physiologic and mechanical consequences of pregnancy. Diuretics are indicated in pregnancy when edema is due to pathologic causes, just as they are in the absence of pregnancy. Dependent edema in pregnancy resulting from restriction of venous return by the expanded uterus is properly treated through elevation of the lower extremities and use of support hose; use of diuretics to lower intravascular volume in this case is illogical and unnecessary. There is hypervolemia during normal pregnancy which is harmful to neither the fetus nor the mother (in the absence of cardiovascular disease), but which is associated with edema, including generalized edema in the majority of pregnant women. If this edema produces discomfort, increased recumbency will often provide relief. In rare instances this edema may cause extreme discomfort which is not relieved by rest. In these cases a short course of diuretics may provide relief and may be appropriate.

 

History

There is currently no drug history available for this drug.

Other Information

Hydrochlorothiazide is the 3,4-dihydro derivative of chlorothiazide. Its chemical name is 6-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide. Its molecular formula is C7H8ClN3O4S2; its molecular weight is 297.74; and its structural formula is:

MM1

It is a white, or practically white, crystalline powder which is slightly soluble in water, but freely soluble in sodium hydroxide solution.

Hydrochlorothiazide is supplied as 12.5 mg capsules for oral use.

Inactive ingredients: microcrystalline cellulose, pregelatinized starch, colloidal silicon dioxide, magnesium stearate, gelatin, titanium dioxide, sodium lauryl sulfate and black iron oxide.

 

Hydrochlorothiazide Manufacturers


  • Remedyrepack Inc.
    Hydrochlorothiazide Capsule [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Hydrochlorothiazide Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Hydrochlorothiazide Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Hydrochlorothiazide Tablet [Remedyrepack Inc. ]
  • Preferred Pharmaceuticals, Inc.
    Hydrochlorothiazide Tablet [Preferred Pharmaceuticals, Inc.]
  • Proficient Rx Lp
    Hydrochlorothiazide Tablet [Proficient Rx Lp]
  • Northwind Pharmaceuticals, Llc
    Hydrochlorothiazide Tablet [Northwind Pharmaceuticals, Llc]
  • Blenheim Pharmacal, Inc.
    Hydrochlorothiazide Tablet [Blenheim Pharmacal, Inc.]
  • Blenheim Pharmacal, Inc.
    Hydrochlorothiazide Capsule, Gelatin Coated [Blenheim Pharmacal, Inc.]
  • International Labs, Inc.
    Hydrochlorothiazide Tablet [International Labs, Inc.]
  • Blenheim Pharmacal, Inc.
    Hydrochlorothiazide Tablet [Blenheim Pharmacal, Inc.]
  • Heritage Pharmaceuticals Inc.
    Hydrochlorothiazide Tablet [Heritage Pharmaceuticals Inc.]
  • Heritage Pharmaceuticals Inc.
    Hydrochlorothiazide Tablet [Heritage Pharmaceuticals Inc.]
  • A-s Medication Solutions Llc
    Hydrochlorothiazide Tablet [A-s Medication Solutions Llc]
  • A-s Medication Solutions Llc
    Hydrochlorothiazide Tablet [A-s Medication Solutions Llc]
  • A-s Medication Solutions Llc
    Hydrochlorothiazide Tablet [A-s Medication Solutions Llc]
  • Direct Rx
    Hydrochlorothiazide Capsule [Direct Rx]
  • State Of Florida Doh Central Pharmacy
    Hydrochlorothiazide Capsule [State Of Florida Doh Central Pharmacy]
  • Remedyrepack Inc.
    Hydrochlorothiazide Capsule [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Hydrochlorothiazide Tablet [Remedyrepack Inc. ]
  • Vensun Pharmaceuticals, Inc.
    Hydrochlorothiazide Tablet [Vensun Pharmaceuticals, Inc.]
  • Caraco Pharmaceutical Laboratories, Ltd.
    Hydrochlorothiazide (Hydrochlorothiazide) Tablet [Caraco Pharmaceutical Laboratories, Ltd.]
  • Actavis Elizabeth Llc
    Hydrochlorothiazide Tablet [Actavis Elizabeth Llc]
  • Ipca Laboratories Limited
    Hydrochlorothiazide Capsule [Ipca Laboratories Limited]
  • Heritage Pharmaceuticals Inc
    Hydrochlorothiazide Capsule [Heritage Pharmaceuticals Inc]
  • Apotex Corp.
    Hydrochlorothiazide Tablet [Apotex Corp.]
  • Contract Pharmacy Services-pa
    Hydrochlorothiazide Tablet [Contract Pharmacy Services-pa]
  • Apotheca, Inc.
    Hydrochlorothiazide Tablet [Apotheca, Inc.]
  • Stat Rx Usa Llc
    Hydrochlorothiazide Tablet [Stat Rx Usa Llc]
  • Kaiser Foundation Hospitals
    Hydrochlorothiazide Tablet [Kaiser Foundation Hospitals]
  • Contract Pharmacy Services-pa
    Hydrochlorothiazide Tablet [Contract Pharmacy Services-pa]
  • State Of Florida Doh Central Pharmacy
    Hydrochlorothiazide Capsule [State Of Florida Doh Central Pharmacy]
  • State Of Florida Doh Central Pharmacy
    Hydrochlorothiazide Tablet [State Of Florida Doh Central Pharmacy]
  • State Of Florida Doh Central Pharmacy
    Hydrochlorothiazide Capsule, Gelatin Coated Hydrochlorothiazide Tablet [State Of Florida Doh Central Pharmacy]
  • Stat Rx Usa Llc
    Hydrochlorothiazide Capsule, Gelatin Coated [Stat Rx Usa Llc]
  • Rebel Distributors Corp
    Hydrochlorothiazide Tablet [Rebel Distributors Corp]
  • Contract Pharmacy Services-pa
    Hydrochlorothiazide Tablet [Contract Pharmacy Services-pa]
  • Ncs Healthcare Of Ky, Inc Dba Vangard Labs
    Hydrochlorothiazide Tablet [Ncs Healthcare Of Ky, Inc Dba Vangard Labs]
  • Physicians Total Care, Inc.
    Hydrochlorothiazide Capsule [Physicians Total Care, Inc.]
  • Heritage Pharmaceuticals Inc.
    Hydrochlorothiazide Tablet [Heritage Pharmaceuticals Inc.]
  • Northstar Rxllc
    Hydrochlorothiazide Capsule [Northstar Rxllc]
  • Remedyrepack Inc.
    Hydrochlorothiazide Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Hydrochlorothiazide Capsule [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Hydrochlorothiazide Tablet [Remedyrepack Inc. ]
  • West-ward Pharmaceutical Corp
    Hydrochlorothiazide Capsule [West-ward Pharmaceutical Corp]
  • Redpharm Drug Inc.
    Hydrochlorothiazide Capsule, Gelatin Coated [Redpharm Drug Inc.]
  • Remedyrepack Inc.
    Hydrochlorothiazide Tablet [Remedyrepack Inc. ]
  • Lannett Company, Inc.
    Hydrochlorothiazide Tablet [Lannett Company, Inc.]
  • Pd-rx Pharmaceuticals, Inc.
    Hydrochlorothiazide Capsule, Gelatin Coated [Pd-rx Pharmaceuticals, Inc.]
  • Remedyrepack Inc.
    Hydrochlorothiazide (Hydrochlorothiazide) Capsule [Remedyrepack Inc. ]
  • St Marys Medical Park Pharmacy
    Hydrochlorothiazide Tablet [St Marys Medical Park Pharmacy]
  • Rebel Distributors Corp
    Hydrochlorothiazide Tablet [Rebel Distributors Corp]
  • Remedyrepack Inc.
    Hydrochlorothiazide Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Hydrochlorothiazide Tablet [Remedyrepack Inc. ]
  • Dispensing Solutions, Inc.
    Hydrochlorothiazide Tablet [Dispensing Solutions, Inc.]
  • Pd-rx Pharmaceuticals, Inc.
    Hydrochlorothiazide Tablet [Pd-rx Pharmaceuticals, Inc.]
  • Jubilant Cadista Pharmaceuticals, Inc.
    Hydrochlorothiazide (Hydrochlorothiazide) Capsule, Gelatin Coated [Jubilant Cadista Pharmaceuticals, Inc.]
  • Jubilant Cadista Pharmaceuticals, Inc.
    Hydrochlorothiazide (Hydrochlorothiazide) Tablet [Jubilant Cadista Pharmaceuticals, Inc.]
  • Unit Dose Services
    Hydrochlorothiazide Capsule, Gelatin Coated [Unit Dose Services]
  • H.j. Harkins Company, Inc.
    Hydrochlorothiazide (Hydrochlorothiazide) Tablet [H.j. Harkins Company, Inc.]
  • Lake Erie Medical & Surgical Supply Dba Quality Care Products Llc
    Hydrochlorothiazide Capsule, Gelatin Coated [Lake Erie Medical & Surgical Supply Dba Quality Care Products Llc]
  • West-ward Pharmaceutical Corp
    Hydrochlorothiazide Tablet [West-ward Pharmaceutical Corp]
  • Pd-rx Pharmaceuticals, Inc.
    Hydrochlorothiazide Tablet [Pd-rx Pharmaceuticals, Inc.]
  • Legacy Pharmaceutical Packaging
    Hydrochlorothiazide Tablet [Legacy Pharmaceutical Packaging]
  • Aurobindo Pharma Limited
    Hydrochlorothiazide Tablet [Aurobindo Pharma Limited]
  • Lannett Company, Inc.
    Hydrochlorothiazide Capsule [Lannett Company, Inc.]
  • Life Line Home Care Services, Inc.
    Hydrochlorothiazide Capsule [Life Line Home Care Services, Inc.]
  • Legacy Pharmaceutical Packaging
    Hydrochlorothiazide Capsule, Gelatin Coated [Legacy Pharmaceutical Packaging]
  • Remedyrepack Inc.
    Hydrochlorothiazide Tablet [Remedyrepack Inc. ]
  • Cardinal Health
    Hydrochlorothiazide Tablet [Cardinal Health]
  • Lake Erie Medical & Surgical Supply Dba Quality Care Products Llc
    Hydrochlorothiazide Tablet [Lake Erie Medical & Surgical Supply Dba Quality Care Products Llc]
  • Watson Laboratories, Inc.
    Hydrochlorothiazide Capsule, Gelatin Coated [Watson Laboratories, Inc.]
  • Rebel Distributors Corp
    Hydrochlorothiazide Tablet [Rebel Distributors Corp]
  • Mckesson Contract Packaging
    Hydrochlorothiazide Capsule, Gelatin Coated [Mckesson Contract Packaging]
  • Mckesson Contract Packaging
    Hydrochlorothiazide Tablet [Mckesson Contract Packaging]
  • Physicians Total Care, Inc.
    Hydrochlorothiazide Tablet [Physicians Total Care, Inc.]
  • Lake Erie Medical & Surgical Supply Dba Quality Care Products Llc
    Hydrochlorothiazide Tablet [Lake Erie Medical & Surgical Supply Dba Quality Care Products Llc]
  • Mylan Pharmaceuticals Inc.
    Hydrochlorothiazide Capsule [Mylan Pharmaceuticals Inc.]
  • Stat Rx Usa Llc
    Hydrochlorothiazide Tablet [Stat Rx Usa Llc]
  • Excellium Pharmaceutical Inc.
    Hydrochlorothiazide Tablet [Excellium Pharmaceutical Inc.]
  • Bryant Ranch Prepack
    Hydrochlorothiazide Tablet [Bryant Ranch Prepack]
  • Bryant Ranch Prepack
    Hydrochlorothiazide Tablet [Bryant Ranch Prepack]
  • Aurobindo Pharma Limited
    Hydrochlorothiazide Capsule [Aurobindo Pharma Limited]
  • Pd-rx Pharmaceuticals, Inc.
    Hydrochlorothiazide Capsule [Pd-rx Pharmaceuticals, Inc.]
  • Accord Healthcare Inc.
    Hydrochlorothiazide (Hydrochlorothiazide) Tablet [Accord Healthcare Inc.]
  • Med-health Pharma, Llc
    Hydrochlorothiazide Tablet [Med-health Pharma, Llc]
  • Remedyrepack Inc.
    Hydrochlorothiazide Tablet [Remedyrepack Inc. ]
  • Rebel Distributors Corp
    Hydrochlorothiazide Tablet [Rebel Distributors Corp]
  • Medvantx, Inc.
    Hydrochlorothiazide Tablet [Medvantx, Inc.]
  • Remedyrepack Inc.
    Hydrochlorothiazide Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Hydrochlorothiazide Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Hydrochlorothiazide Capsule, Gelatin Coated [Remedyrepack Inc. ]
  • Apotex Corp.
    Hydrochlorothiazide Capsule, Gelatin Coated [Apotex Corp.]
  • Remedyrepack Inc.
    Hydrochlorothiazide Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Hydrochlorothiazide Tablet [Remedyrepack Inc. ]
  • St Marys Medical Park Pharmacy
    Hydrochlorothiazide Capsule [St Marys Medical Park Pharmacy]
  • Ncs Healthcare Of Ky, Inc Dba Vangard Labs
    Hydrochlorothiazide Capsule, Gelatin Coated [Ncs Healthcare Of Ky, Inc Dba Vangard Labs]
  • Blenheim Pharmacal, Inc.
    Hydrochlorothiazide Tablet [Blenheim Pharmacal, Inc.]
  • Qualitest Pharmaceuticals
    Hydrochlorothiazide Capsule, Gelatin Coated [Qualitest Pharmaceuticals]
  • Lake Erie Medical Dba Quality Care Products Llc
    Hydrochlorothiazide Capsule [Lake Erie Medical Dba Quality Care Products Llc]
  • Remedyrepack Inc.
    Hydrochlorothiazide Tablet [Remedyrepack Inc. ]
  • Medvantx, Inc.
    Hydrochlorothiazide Capsule [Medvantx, Inc.]
  • Dava Pharmaceuticals, Inc.
    Hydrochlorothiazide Tablet [Dava Pharmaceuticals, Inc.]
  • A-s Medication Solutions Llc
    Hydrochlorothiazide Tablet [A-s Medication Solutions Llc]
  • Pd-rx Pharmaceuticals, Inc.
    Hydrochlorothiazide Tablet [Pd-rx Pharmaceuticals, Inc.]
  • Qualitest Pharmaceuticals
    Hydrochlorothiazide Tablet [Qualitest Pharmaceuticals]
  • Remedyrepack Inc.
    Hydrochlorothiazide Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Hydrochlorothiazide Capsule [Remedyrepack Inc. ]
  • American Health Packaging
    Hydrochlorothiazide Capsule [American Health Packaging]
  • Actavis Elizabeth Llc
    Hydrochlorothiazide Tablet [Actavis Elizabeth Llc]
  • St Marys Medical Park Pharmacy
    Hydrochlorothiazide Tablet [St Marys Medical Park Pharmacy]
  • Lake Erie Medical Dba Quality Care Products Llc
    Hydrochlorothiazide Tablet [Lake Erie Medical Dba Quality Care Products Llc]
  • Liberty Pharmaceuticals, Inc.
    Hydrochlorothiazide Tablet [Liberty Pharmaceuticals, Inc.]
  • Remedyrepack Inc.
    Hydrochlorothiazide Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Hydrochlorothiazide Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Hydrochlorothiazide Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Hydrochlorothiazide Tablet [Remedyrepack Inc. ]
  • International Labs, Inc.
    Hydrochlorothiazide Tablet [International Labs, Inc.]
  • Unit Dose Services
    Hydrochlorothiazide Tablet [Unit Dose Services]
  • Remedyrepack Inc.
    Hydrochlorothiazide Capsule [Remedyrepack Inc. ]
  • Aidarex Pharmaceuticals Llc
    Hydrochlorothiazide Capsule, Gelatin Coated [Aidarex Pharmaceuticals Llc]
  • Aidarex Pharmaceuticals Llc
    Hydrochlorothiazide Tablet [Aidarex Pharmaceuticals Llc]
  • Heritage Pharmaceuticals Inc.
    Hydrochlorothiazide Tablet [Heritage Pharmaceuticals Inc.]
  • American Health Packaging
    Hydrochlorothiazide Tablet [American Health Packaging]
  • Unichem Pharmaceuticals (Usa), Inc.
    Hydrochlorothiazide Capsule [Unichem Pharmaceuticals (Usa), Inc.]
  • Unichem Pharmaceuticals (Usa), Inc.
    Hydrochlorothiazide Tablet [Unichem Pharmaceuticals (Usa), Inc.]
  • Blenheim Pharmacal, Inc.
    Hydrochlorothiazide Tablet [Blenheim Pharmacal, Inc.]
  • Mckesson Packaging Services A Business Unit Of Mckesson Corporation
    Hydrochlorothiazide Tablet [Mckesson Packaging Services A Business Unit Of Mckesson Corporation]
  • International Labs, Inc.
    Hydrochlorothiazide Tablet [International Labs, Inc.]
  • Ivax Pharmaceuticals, Inc.
    Hydrochlorothiazide Tablet [Ivax Pharmaceuticals, Inc.]
  • Greenstone Llc
    Hydrochlorothiazide Capsule [Greenstone Llc]
  • Cardinal Health
    Hydrochlorothiazide Tablet [Cardinal Health]
  • Unit Dose Services
    Hydrochlorothiazide Tablet [Unit Dose Services]
  • Direct Rx
    Hydrochlorothiazide Tablet [Direct Rx]
  • State Of Florida Doh Central Pharmacy
    Hydrochlorothiazide Tablet [State Of Florida Doh Central Pharmacy]
  • State Of Florida Doh Central Pharmacy
    Hydrochlorothiazide Capsule, Gelatin Coated [State Of Florida Doh Central Pharmacy]
  • Caraco Pharmaceutical Laboratories, Ltd.
    Hydrochlorothiazide Capsule [Caraco Pharmaceutical Laboratories, Ltd.]
  • Aphena Pharma Solutions – Tennessee, Llc
    Hydrochlorothiazide Tablet [Aphena Pharma Solutions – Tennessee, Llc]
  • Cardinal Health
    Hydrochlorothiazide Capsule [Cardinal Health]
  • Preferred Pharmaceuticals, Inc.
    Hydrochlorothiazide Capsule [Preferred Pharmaceuticals, Inc.]
  • Preferred Pharmaceuticals, Inc.
    Hydrochlorothiazide Tablet [Preferred Pharmaceuticals, Inc.]
  • Proficient Rx Lp
    Hydrochlorothiazide Tablet [Proficient Rx Lp]
  • Preferred Pharmaceuticals, Inc.
    Hydrochlorothiazide Tablet [Preferred Pharmaceuticals, Inc.]
  • Readymeds
    Hydrochlorothiazide Tablet [Readymeds]
  • Aphena Pharma Solutions – Tennessee, Llc
    Hydrochlorothiazide Capsule, Gelatin Coated [Aphena Pharma Solutions – Tennessee, Llc]
  • Aphena Pharma Solutions – Tennessee, Llc
    Hydrochlorothiazide Tablet [Aphena Pharma Solutions – Tennessee, Llc]
  • Readymeds
    Hydrochlorothiazide Capsule [Readymeds]
  • Remedyrepack Inc.
    Hydrochlorothiazide Capsule, Gelatin Coated [Remedyrepack Inc. ]
  • Golden State Medical Supply, Inc
    Hydrochlorothiazide Tablet [Golden State Medical Supply, Inc]
  • Sciegen Pharmaceuticals, Inc.
    Hydrochlorothiazide Tablet [Sciegen Pharmaceuticals, Inc.]
  • Remedyrepack Inc.
    Hydrochlorothiazide Tablet [Remedyrepack Inc. ]
  • Heritage Pharmaceuticals Inc.
    Hydrochlorothiazide Capsule [Heritage Pharmaceuticals Inc.]
  • Bryant Ranch Prepack
    Hydrochlorothiazide Capsule, Gelatin Coated [Bryant Ranch Prepack]
  • Carilion Materials Management
    Hydrochlorothiazide Tablet [Carilion Materials Management]
  • Citron Pharma Llc
    Hydrochlorothiazide Capsule [Citron Pharma Llc]
  • Tya Pharmaceuticals
    Hydrochlorothiazide Tablet [Tya Pharmaceuticals]
  • Northwind Pharmaceuticals, Llc
    Hydrochlorothiazide Tablet [Northwind Pharmaceuticals, Llc]
  • Northwind Pharmaceuticals, Llc
    Hydrochlorothiazide Tablet [Northwind Pharmaceuticals, Llc]
  • Cardinal Health
    Hydrochlorothiazide Tablet [Cardinal Health]
  • Mylan Institutional Inc.
    Hydrochlorothiazide Capsule [Mylan Institutional Inc.]
  • State Of Florida Doh Central Pharmacy
    Hydrochlorothiazide Capsule [State Of Florida Doh Central Pharmacy]
  • Remedyrepack Inc.
    Hydrochlorothiazide Tablet [Remedyrepack Inc. ]
  • Proficient Rx Lp
    Hydrochlorothiazide Capsule, Gelatin Coated [Proficient Rx Lp]
  • Proficient Rx Lp
    Hydrochlorothiazide Tablet [Proficient Rx Lp]
  • Preferred Pharmaceuticals Inc.
    Hydrochlorothiazide Tablet [Preferred Pharmaceuticals Inc.]

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