Lisinopril

Lisinopril (brand names include Prinivil, Qbrelis, and Zestril) is primarily used to treat hypertension in humans, dogs, and cats. It is also prescribed to protect and treat the kidneys, prevent heart failure, and reduce fluid. It helps blood and oxygen reach the brain and body better. Serious side effects include jaundice, confusion, flu-like symptoms, and chest pain. This medication can be dangerous if administered to pregnant and nursing women, individuals with diabetes, and those who have kidney, heart, or liver disease.

Lisinopril

Lisinopril Recall

In 2016, Lupin Pharmaceuticals Inc recalled 30mg and 40mg bottles of Lisinopril tablets as a result of contamination during manufacturing. The previous year, Wockhardt recalled its 5mg and 20mg tablets for the same reason.

As of August 2016, the FDA has banned three of their manufacturing facilities. At least two plants were banned for ignoring consumer complaints and not meeting sanitation requirements and a third for undisclosed reasons. The company was also found guilty of fabricating drug testing and destroying records.

Questions & Answers

Side Effects & Adverse Reactions

Serious adverse reactions include unusual fatigue, blurry vision, dizziness upon standing, confusion, sweating, yellowing of the skin/eyes, reduced urination, and urine that appears cloudy. Less commonly reported include chills, chest pain, trouble breathing, pain in the stomach or abdomen, cold and flu symptoms (including sore throat and body aches), nausea, and headache. Muscle pain, insomnia, appetite loss, joint pain, chest pain, irregular or fast heartbeat, jaw, arm, or back pain, and shivering are rare but serious reactions and should be reported to a healthcare professional.

Less serious complaints involve patients experiencing difficulty producing or sustaining an erection, a decrease in sexual desire or performance, and rash. Rarely, heartburn, sour stomach, indigestion, gas, muscle cramps, a spinning sensation, and itching, burning, tingling, and numbness result from taking Zestril - however, these are not typically major causes for concern.

Lisinopril can cause low blood pressure, severe swelling (Angioedema), and serious kidney and liver problems. It should not be taken with alcohol. Pregnant women should not use it because it may cause harm to a developing fetus. This medication can be dangerous for people with an electrolyte imbalance, liver, kidney, heart, or blood disease, and for those with diabetes. You should not take it if you have an allergy to ACE inhibitors or lisinopril. The efficacy of this medication has not been proven effective in children less than 6 years of age. Never combine it with Aliskiren or Sacubitril.

Legal Issues

Many individuals have suffered renal system complications after using this medication - although no class action lawsuits currently exist.

FDA Safety Alerts

Be sure to have your doctor monitor your electrolytes, blood pressure, and renal function if you are using Prinivil (lisinopril) or other medications that influence the RAAS. Do not take it with aliskiren if you have diabetes or renal impairment.

Manufacturer Warnings

There is currently no manufacturer warning information available for this drug.

FDA Labeling Changes

Pregnant women should not use this medication as it causes renal function impairment and failure and increases the risk of death in fetuses during the second and third trimesters. Additionally, low blood pressure and skeletal irregularities such as skull hypoplasia have also been reported in fetuses. Lisinopril should only be used by pregnant women as a last resort. Fetuses and infants exposed to it in utero should be monitored regularly by medical professionals for issues including oliguria (urine production deficiency), hyperkalemia (high blood potassium), and hypotension. Women who breastfeed should not use this drug as it may contaminate milk.

There is an increased risk for angioedema in people taking mTOR (mammalian target of rapamycin) inhibitor therapy - especially those that also use an ACE inhibitor. Elderly individuals, people with impaired renal function, and those that are on diuretic therapy should not take lisinopril with NSAIDs as it can worsen renal function and result in acute renal failure. These side effects are typically reversible. People that must take them together should have their renal function monitored regularly. Additionally, the effectiveness of lisinopril may be reduced if taken with NSAIDs.

A study revealed that losartan and lisinopril together are no more effective in treating end stage renal disease than a single therapy. However, participants who did use them concurrently had an increased incidence of acute kidney injury and high potassium levels in their blood when compared to those in the single therapy group.

Additionally, Lisinopril can cause mood changes (including depression), disturbances in the olfactory system (which controls smell), psoriasis, and hallucinations.

Uses

Lisinopril is a prescription ACE inhibitor medication that is available in both tablet and liquid solution form (angiotensin converting enzyme). It is used to treat hypertension (high blood pressure) - a condition that if left untreated can lead to impaired functioning of the arteries and heart. Damage to the heart, blood vessels of the brain, and kidneys can lead to heart failure, stroke, or kidney failure. Lisinopril is also used to protect the kidneys from harm due to diabetes. It also decreases the risk of heart attack (myocardial infarction) and stroke. Prinivil is prescribed for heart failure and to people after they’ve had a heart attack. It widens the blood vessels by blocking a chemical in the body that restricts blood flow. The results are lower blood pressure and more blood and oxygen delivered to the heart.

Heart muscles are weakened and damaged after an attack and pumping blood becomes more taxing. The survival rate is improved when Qbrelis is administered during the 24 hours following a heart attack.

This medication also reduces fluid retention, dilates veins, and treats certain types of kidney disease, heart failure, and high blood pressure in dogs and cats.

History

Merck initially started making Prinivil (lisinopril oral tablets) in 1987. It was initially available in 5mg, 10mg, and 20mg tablets. In 1988, the 40mg strength tablets became available and the FDA approved 2.5 mg tablets six years later. Alvogen Malta started selling their brand of lisinopril - Zestril (lisinopril oral tablets) - in 1988 and it was available in 5mg, 10mg, and 20mg strengths.

The generic version of lisinopril became available in 2007 and is sold in in 5mg, 10mg, 20mg, and 40mg tablet form. Wockhardt - an Indian pharmaceutical company - produces it. It has since become available by many others including Watson Labs, Mylan, and Sandoz.

In 2016, Silvergate Pharmaceuticals released Qbrelis - a 1mg/ml solution.

Other Information

Lisinopril is an oral long-acting angiotensin converting enzyme (ACE) inhibitor.  Lisinopril, a synthetic peptide derivative, is chemically described as (S)-1-[N2-(1-carboxy-3-phenylpropyl)-L-lysyl]-L-proline dihydrate.  Its empirical formula is C21H31N3O52H2O and its structural formula is:

MM1 

Lisinopril USP is a white to off-white, crystalline powder, with a molecular weight of 441.53.  It is soluble in water and sparingly soluble in methanol and practically insoluble in ethanol.

Lisinopril is supplied as 2.5 mg, 5 mg, 10 mg, 20 mg, 30 mg and 40 mg tablets for oral administration.

Lisinopril Tablets 2.5 mg, 5 mg, 10 mg, 20 mg, 30 mg and 40 mg contain the following inactive ingredients: corn starch, dibasic calcium phosphate dihydrate, magnesium stearate, mannitol and talc.

 

http://www.fda.gov/safety/medwatch/safetyinformation/ucm283115.htm

http://www.fda.gov/safety/medwatch/safetyinformation/ucm270998.htm

http://www.fda.gov/safety/medwatch/safetyinformation/ucm165413.htm

http://www.fda.gov/safety/medwatch/safetyinformation/ucm271344.htm

http://www.fda.gov/safety/medwatch/safetyinformation/ucm193821.htm

http://www.firstpost.com/business/lupin-dr-reddys-recall-1-7-lakh-blood-pressure-acidity-tablets-in-us-2878676.html

http://www.firstpost.com/business/sun-wockhardt-recall-drugs-from-us-market-2413690.html

http://www.firstpost.com/business/sun-wockhardt-recall-drugs-from-us-market-2413690.html

http://www.ncbi.nlm.nih.gov/pubmedhealth/PMHT0010968/?report=details

https://www.drugs.com/sfx/lisinopril-side-effects.html

http://www.1800petmeds.com/Lisinopril-prod11197.html

Lisinopril Manufacturers


  • Remedyrepack Inc.
    Lisinopril Tablet [Remedyrepack Inc. ]
  • Cardinal Health
    Lisinopril Tablet [Cardinal Health]
  • Remedyrepack Inc.
    Lisinopril Tablet [Remedyrepack Inc. ]
  • Major Pharmaceuticals
    Lisinopril Tablet [Major Pharmaceuticals]
  • Remedyrepack Inc.
    Lisinopril Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Lisinopril Tablet [Remedyrepack Inc. ]
  • Proficient Rx Lp
    Lisinopril Tablet [Proficient Rx Lp]
  • International Labs, Inc.
    Lisinopril Tablet [International Labs, Inc.]
  • Golden State Medical Supply, Inc.
    Lisinopril Tablet [Golden State Medical Supply, Inc.]
  • Remedyrepack Inc.
    Lisinopril Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Lisinopril Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Lisinopril Tablet [Remedyrepack Inc. ]
  • Northwind Pharmaceuticals, Llc
    Lisinopril Tablet [Northwind Pharmaceuticals, Llc]
  • Blenheim Pharmacal, Inc.
    Lisinopril Tablet [Blenheim Pharmacal, Inc.]
  • Remedyrepack Inc.
    Lisinopril Tablet [Remedyrepack Inc. ]
  • Direct Rx
    Lisinopril Tablet [Direct Rx]
  • Direct Rx
    Lisinopril Tablet [Direct Rx]
  • Solco Healthcare U.s., Llc
    Lisinopril Tablet [Solco Healthcare U.s., Llc]
  • State Of Florida Doh Central Pharmacy
    Lisinopril Tablet [State Of Florida Doh Central Pharmacy]
  • American Health Packaging
    Lisinopril Tablet [American Health Packaging]
  • Northwind Pharmaceuticals, Llc
    Lisinopril Tablet [Northwind Pharmaceuticals, Llc]
  • Rxchange Co.
    Lisinopril Tablet [Rxchange Co.]
  • Northwind Pharmaceuticals, Llc
    Lisinopril Tablet [Northwind Pharmaceuticals, Llc]
  • Rxchange Co.
    Lisinopril Tablet [Rxchange Co.]
  • Cardinal Health
    Lisinopril Tablet [Cardinal Health]
  • Proficient Rx Lp
    Lisinopril Tablet [Proficient Rx Lp]
  • Tya Pharmaceuticals
    Lisinopril Tablet [Tya Pharmaceuticals]
  • Contract Pharmacy Services-pa
    Lisinopril Tablet [Contract Pharmacy Services-pa]
  • State Of Florida Doh Central Pharmacy
    Lisinopril Tablet [State Of Florida Doh Central Pharmacy]
  • State Of Florida Doh Central Pharmacy
    Lisinopril Tablet [State Of Florida Doh Central Pharmacy]
  • State Of Florida Doh Central Pharmacy
    Lisinopril Tablet [State Of Florida Doh Central Pharmacy]
  • State Of Florida Doh Central Pharmacy
    Lisinopril Tablet [State Of Florida Doh Central Pharmacy]
  • Contract Pharmacy Services-pa
    Lisinopril Tablet [Contract Pharmacy Services-pa]
  • Blenheim Pharmacal, Inc.
    Lisinopril Tablet [Blenheim Pharmacal, Inc.]
  • Blenheim Pharmacal, Inc.
    Lisinopril Tablet [Blenheim Pharmacal, Inc.]
  • Blenheim Pharmacal, Inc.
    Lisinopril Tablet [Blenheim Pharmacal, Inc.]
  • Keltman Pharmaceuticals Inc.
    Lisinopril Tablet [Keltman Pharmaceuticals Inc.]
  • Remedyrepack Inc.
    Lisinopril Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Lisinopril Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Lisinopril Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Lisinopril Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Lisinopril Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Lisinopril Tablet [Remedyrepack Inc. ]
  • Stat Rx Usa Llc
    Lisinopril Tablet [Stat Rx Usa Llc]
  • Remedyrepack Inc.
    Lisinopril Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Lisinopril Tablet [Remedyrepack Inc. ]
  • Legacy Pharmaceutical Packaging
    Lisinopril Tablet [Legacy Pharmaceutical Packaging]
  • Remedyrepack Inc.
    Lisinopril Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Lisinopril Tablet [Remedyrepack Inc. ]
  • Redpharm Drug Inc.
    Lisinopril Tablet [Redpharm Drug Inc.]
  • Redpharm Drug Inc.
    Lisinopril Tablet [Redpharm Drug Inc.]
  • Pd-rx Pharmaceuticals, Inc.
    Lisinopril Tablet [Pd-rx Pharmaceuticals, Inc.]
  • Redpharm Drug Inc.
    Lisinopril Tablet [Redpharm Drug Inc.]
  • St Marys Medical Park Pharmacy
    Lisinopril Tablet [St Marys Medical Park Pharmacy]
  • Unit Dose Services
    Lisinopril Tablet [Unit Dose Services]
  • Remedyrepack Inc.
    Lisinopril (Lisinopril) Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Lisinopril Tablet [Remedyrepack Inc. ]
  • Pd-rx Pharmaceuticals, Inc.
    Lisinopril (Lisinopril) Tablet [Pd-rx Pharmaceuticals, Inc.]
  • Pd-rx Pharmaceuticals, Inc.
    Lisinopril Tablet [Pd-rx Pharmaceuticals, Inc.]
  • Rebel Distributors Corp
    Lisinopril Tablet [Rebel Distributors Corp]
  • Rebel Distributors Corp
    Lisinopril Tablet [Rebel Distributors Corp]
  • H.j. Harkins Company, Inc.
    Lisinopril Tablet [H.j. Harkins Company, Inc.]
  • Life Line Home Care Services, Inc.
    Lisinopril Tablet [Life Line Home Care Services, Inc.]
  • Wockhardt Usa Llc.
    Lisinopril Tablet [Wockhardt Usa Llc.]
  • Wockhardt Limited
    Lisinopril Tablet [Wockhardt Limited]
  • Preferred Pharmaceuticals, Inc
    Lisinopril Tablet [Preferred Pharmaceuticals, Inc]
  • Mckesson Contract Packaging
    Lisinopril Tablet [Mckesson Contract Packaging]
  • Physicians Total Care, Inc.
    Lisinopril Tablet [Physicians Total Care, Inc.]
  • Mylan Institutional Inc.
    Lisinopril Tablet [Mylan Institutional Inc.]
  • Stat Rx Usa Llc
    Lisinopril Tablet Lisinopril Tablet [Stat Rx Usa Llc]
  • Bryant Ranch Prepack
    Lisinopril Tablet [Bryant Ranch Prepack]
  • Bryant Ranch Prepack
    Lisinopril Tablet [Bryant Ranch Prepack]
  • Bryant Ranch Prepack
    Lisinopril Tablet [Bryant Ranch Prepack]
  • Remedyrepack Inc.
    Lisinopril (Lisinopril ) Tablet [Remedyrepack Inc. ]
  • Lake Erie Medical Dba Quality Care Products Llc
    Lisinopril Tablet [Lake Erie Medical Dba Quality Care Products Llc]
  • Remedyrepack Inc.
    Lisinopril Tablet [Remedyrepack Inc. ]
  • Pd-rx Pharmaceuticals, Inc.
    Lisinopril Tablet [Pd-rx Pharmaceuticals, Inc.]
  • Remedyrepack Inc.
    Lisinopril Tablet [Remedyrepack Inc. ]
  • Ncs Healthcare Of Ky, Inc Dba Vangard Labs
    Lisinopril Tablet, Film Coated [Ncs Healthcare Of Ky, Inc Dba Vangard Labs]
  • Remedyrepack Inc.
    Lisinopril Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Lisinopril Tablet [Remedyrepack Inc. ]
  • Ncs Healthcare Of Ky, Inc Dba Vangard Labs
    Lisinopril Tablet [Ncs Healthcare Of Ky, Inc Dba Vangard Labs]
  • Remedyrepack Inc.
    Lisinopril Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Lisinopril Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Lisinopril Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Lisinopril Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Lisinopril Tablet [Remedyrepack Inc. ]
  • Med-health Pharma, Llc
    Lisinopril Tablet [Med-health Pharma, Llc]
  • Cardinal Health
    Lisinopril Tablet [Cardinal Health]
  • Remedyrepack Inc.
    Lisinopril Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Lisinopril Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Lisinopril Tablet [Remedyrepack Inc. ]
  • Blu Pharmaceuticals, Llc
    Lisinopril Tablet [Blu Pharmaceuticals, Llc]
  • Remedyrepack Inc.
    Lisinopril Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Lisinopril Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Lisinopril Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Lisinopril Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Lisinopril Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Lisinopril Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Lisinopril Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Lisinopril Tablet [Remedyrepack Inc. ]
  • St Marys Medical Park Pharmacy
    Lisinopril Tablet [St Marys Medical Park Pharmacy]
  • Remedyrepack Inc.
    Lisinopril Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Lisinopril Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Lisinopril Tablet [Remedyrepack Inc. ]
  • Lake Erie Medical Dba Quality Care Products Llc
    Lisinopril Tablet [Lake Erie Medical Dba Quality Care Products Llc]