Anazaohealth Corporation

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Anazaohealth Corporation Drugs

Sincalide

Sincalide

To reconstitute, aseptically add 3 mL of preservative free 0.9% sodium chloride to the vial and swirl. This solution may be kept at room temperature and should be used within 8 hours of reconstitution, after which time any unused portion should be discarded.

The vial should be inspected visually for particulate matter and discoloration prior to administration.

For prompt contraction of the gallbladder, a dose of 0.02 mcg sincalide per kg (1.4 mcg/70 kg) is injected intravenously over a 30- to 60-second interval; if satisfactory contraction of the gallbladder does not occur in 15 minutes, a second dose, 0.04 mcg sincalide per kg, may be administered. To reduce the intestinal side effects, an intravenous infusion may be prepared at a dose of 0.12 mcg/kg in 100 mL of Sodium Chloride Injection USP and given at a rate of 2 mL per minute; alternatively, an intramuscular dose of 0.1 mcg/kg may be given.

To accelerate the transit time of a barium meal through the small bowel, administer Sincalide after the barium meal is beyond the proximal jejunum. (Sincalide, like cholecystokinin, may cause pyloric contraction.) The recommended dose is 0.04 mcg sincalide per kg (2.8 mcg/70 kg) injected intravenously over a 30- to 60- second interval; if satisfactory transit of the barium meal has not occurred in 30 minutes, a second dose of 0.04 mcg sincalide per kg may be administered. For reduction of side effects, a 30-minute IV infusion of sincalide [0.12 mcg per kg (8.4 mcg/70 kg) diluted to approximately 100 mL with Sodium Chloride Injection USP] may be administered

Storage and Handling

The preparation should be stored at room temperature
Tetrofosmin

Tetrofosmin

Depending on the protocol for rest/stress imaging, doses of 10 to 30 mCi (370 to 1110 MBq) are given intravenously

PREPARATION
Snap off the plastic lid and place in appropriate lead shielding. Wipe the septum with 70% isopropyl alcohol and allow it to dry. Using a 10 mL syringe, dilute up to 360 mCi of Tc99m with saline and add to vial. The total volume should be between 6 mL -12 mL and the Tc99m concentration should not exceed 30 mCi/mL (360 mCi/12 mL). After adding the Tc99m, insert a 0.22 µm filtered vent needle and, using a separate syringe, withdraw 3 mL of gas from the vial, allowing sterile filtered air into the vial. Remove vent needle and syringe. Mix gently and invert several times for 10 seconds. Let stand for 15 minutes at room temperature as the complexes form. Inspect vial through a lead glass shield for particulate matter. Do not use if the solution is not clear. Store at 2°- 8°C (36°- 46°F) and use within 12 hours after mixing. Radiochemical purity should be at least 90% prior to administration QC info: Solvent – Ethyl Acetate, Strip – Whatman CHR% Tag = top counts/total counts X 100%
STORAGE

The preparation should be stored in the refrigerator at 2- 8(C (36 - 46(F) and protected from light.
I 123 Mibg Meta Iodoben...

I 123 Mibg Meta Iodobenzylguanidine

There is currently no dosage information available for this product. We apologize for any inconvenience.
Tetrofosmin

Tetrofosmin

Depending on the protocol for rest/stress imaging, doses of 10 to 30 mCi (370 to 1110 MBq) are given intravenously

PREPARATION
Snap off the plastic lid and place in appropriate lead shielding. Wipe the septum with 70% isopropyl alcohol and allow it to dry. Using a 10 mL syringe, dilute up to 360 mCi of Tc99m with saline and add to vial. The total volume should be between 6 mL -12 mL and the Tc99m concentration should not exceed 30 mCi/mL (360 mCi/12 mL). After adding the Tc99m, insert a 0.22 µm filtered vent needle and, using a separate syringe, withdraw 3 mL of gas from the vial, allowing sterile filtered air into the vial. Remove vent needle and syringe. Mix gently and invert several times for 10 seconds. Let stand for 15 minutes at room temperature as the complexes form. Inspect vial through a lead glass shield for particulate matter. Do not use if the solution is not clear. Store at 2°- 8°C (36°- 46°F) and use within 12 hours after mixing. Radiochemical purity should be at least 90% prior to administration QC info: Solvent – Ethyl Acetate, Strip – Whatman CHR% Tag = top counts/total counts X 100%
STORAGE

The preparation should be stored in the refrigerator at 2- 8(C (36 - 46(F) and protected from light.
Acd Solution Modified S...

Acd Solution Modified Solution

Red Blood Cell Labeling Procedure
Labeling may be performed without washing or centrifugation steps directly in the reaction vial. A 30 to 50 mL sample of whole blood is withdrawn from the patient and added aseptically to a vial of ACD Solution Modified. 50 to 150 microcuries of Sodium Chromate 51 is then injected into the reaction vial using a shielded syringe. The amount of radioactivity added to the vial will
depend on the intended use of the labeled red blood cells.
The suspension is incubated for 30 to 60 minutes at room temperature with frequent, gentle agitation. After incubation, 100 mg Ascorbic Acid Injection is injected into the vial. The ascorbic acid reduces any remaining unbound dianionic chromium 51 to the anionic state which does not penetrate red blood cells; thus in vivo labeling of red blood cells is prevented.
Storage and Handling

Store the product at room temperature
Dipyridamole

Dipyridamole

The recommended dose is 0.142 mg/kg/minute (0.57 mg/kg total) or 0.568 mg/kg or 60 mg total dose infused over 4 minutes. Although the maximum tolerated dose has not been determined, clinical experience suggests that a total dose beyond 60 mg is not needed for any patient.

Prior to intravenous administration, dipyridamole should be diluted in at least a 1:2 ratio with 0.45% sodium chloride injection, 0.9% sodium chloride injection, or 5% dextrose injection for a total volume of approximately 20 to 50 mL. Infusion of undiluted dipyridamole injection may cause local irritation.

Myocardial perfusion assessment should be started when maximal vasodilation is reached, usually after 3 minutes, which generally occurs approximately 7 minutes from onset of infusion
Isosulfan Blue Solution...

Isosulfan Blue Solution

Isosulfan Blue 1% is to be administered subcutaneously, one-half (1/2) ml into three (3) interdigital spaces of each extremity per study. A maximum dose of 3 ml (30 mg) isosulfan blue is injected.
Pentagastrin Solution

Pentagastrin Solution

The intravenous infusion dose has ranged from 0.1 to 12 mcg (0.0001 to 0.012 mg) per kg of body weight per hour administered in a 0.9% sodium chloride injection. It can also be used as a subcutaneous injection for gastric function study with a dose of 6 mcg (0.006 mg) per kg of body weight.
In-111 Dtpa Solution

In-111 Dtpa Solution

Extreme care must be exercised to assure aseptic conditions in intrathecal injections. The maximum recommended intrathecal dose in the average patient (70kg) is 18.5 megabecquerels (500 microcuries). The patient dose should be measured by a suitable radioactivity calibration system immediately prior to administration. Parenteral drug preparations should be inspected visually for particulate matter and discoloration prior to administration whenever solution and container permit.

Storage and Handling

Store vial in its lead shield at a temperature of 5-30º C. Do not freeze
Mebrofenin

Mebrofenin

The suggested intravenous dose range of Technetium Tc 99m Mebrofenin in the average patient (70 kg) is:

Nonjaundiced patient: 74 - 185 MBq (2-5 mCi)

Patient with serum bilirubin level greater than 1.5 mg/dL: 111-370 MBq (3-10 mCi)

The patient should be in a fasting state, 4 hours is preferable. False positives (non-visualization) may result if the gallbladder has been emptied by ingestion of food.

An interval of at least 24 hours should be allowed before repeat examination
Glucoheptonate

Glucoheptonate

There is currently no dosage information available for this product. We apologize for any inconvenience.
P32 Sodium Phosphate So...

P32 Sodium Phosphate Solution

For polycythemia vera, intravenous dosages from 1 to 8 mCi are usually given depending upon the stage of disease and the size of the patient. Repeat doses must be adjusted to individual needs. For chronic leukemia, the individual dose is 6 to 15 mCi, usually administered with concomitant hormone manipulation
Bicisate

Bicisate

The recommended dose for a 70 kg patient is 10-30 mCi
Sestamibi

Sestamibi

There is currently no dosage information available for this product. We apologize for any inconvenience.
P32 Sodium Phosphate

P32 Sodium Phosphate

Shake the vial well before injection.

For intraperitoneal instillation, administer 10-20 mCi

For intrapleural instillation, administer 6 to 12 mCi

Doses for interstitial use should be based on estimated gram weight of tumor, about 0.1 to 0.5 mCi/gm.
Pyrophosphate

Pyrophosphate

The recommended adult dose of Tc99m Pyrophosphate Injection is:
5 to 15 mCi for skeletal imaging 10 to 15 mCi for cardiac imaging one-third (0.33) to the entire vial contents, followed 15 to 20 mCi of sodium pertechnetate Tc 99m, for blood pool imaging
Thyrotropin Releasing H...

Thyrotropin Releasing Hormone Trh

TRH is intended for intravenous administration with the patient in the supine position. The drug is administered as a bolus over a period of 15 to 30 seconds, with the patient remaining supine until all scheduled post injection blood samples have been taken. Blood pressure should be measured before TRH is administered and at frequent intervals during the first 15 minutes thereafter (see WARNINGS). Have the patient urinate before injecting TRH.

Adults: 500 μg. Doses between 200 and 500 μg have been used. 500 μg is considered the optimum dose to give the maximum response in the greatest number of patients. Doses greater than 500 μg are unlikely to elicit a greater TSH response.

Children age 6 to 16 years: 7 μg/kg body weight up to a dose of 500 μg.

Infants and children up to 6 years: Experience is limited in this age group; doses of 7μg/kg have been administered.

One blood sample for TSH assay should be drawn immediately prior to the injection of TRH, and a second sample should be obtained 30 minutes after injection.

The TSH response to TRH is reduced by repetitive administration of the drug. Accordingly, if the TRH test is repeated, an interval of seven days before testing is recommended.

Elevated serum lipids may interfere with the TSH assay. Thus, fasting (except in patients with hypopituitarism) or a low-fat meal is recommended prior to the test.
Sodium Chromate 51 Solu...

Sodium Chromate 51 Solution

The suggested dose range in the average patient (70kg) is:Determination of red blood cell volume or mass-0.37 to 1.11 megabecquerels (10 to 30 microcuries). Study of red blood cell survival time-5.55 megabecquerels (150 microcuries). Evaluation of blood loss-7.40 megabecquerels (200 microcuries)
Exametazime Hmpao

Exametazime Hmpao

Cerebral Scintigraphy

The recommended dose range for IV administration is 10 to 20 mCi (370 to 740 MBq).

Leukocyte (WBC) Labeling

The recommended dose range for IV administration is 7 to 25 mCi (259 to 925 MBq)
I 123 Mini

I 123 Mini

Anti-thyroid therapy of a severely hyperthyroid patient is usually discontinued three to four days before administration of radioiodide. For hyperthyroidism, the usual dose range is 4 to 10 mCi. Toxic nodular goiter and other special situations will require the use of larger doses. For thyroid carcinoma, 50 mCi is the usual dose for ablation of normal thyroid tissue, and 100 to 150 mCi is the usual subsequent therapeutic dose. Waterproof gloves should be used during the entire handling and administration procedure. Adequate shielding must be maintained.
Dextran 75

Dextran 75

To prepare injection, up to 40 mCi of an oxidant-free sodium pertechnetate Tc 99m solution is aseptically injected into the vial, minimum volume 1ml, mix gently and let Dextran dissolve completely for 10 minutes

Storage and Handling

Injection should be administered within 6 hours after preparation. Before and after reconstitution- Store at room temperature
Dimercaptosuccinic Acid...

Dimercaptosuccinic Acid Dmsa

Preparation of Technetium Tc 99m DMSA is done by the following aseptic procedure:
Waterproof gloves should be worn during the preparation Snap off the plastic lid and place room temperature reaction vial in an appropriate lead shield. Swab the rubber closure of the vial with a germicide Inject as close to 1 cc as possible of sterile additive free sodium pertechnetate Tc 99m injection containing up to 1480 MBq (40 mCi) into the vial freshly eluded within 2 hours from a technetium generator. Be sure to maintain inert atmosphere in vial by introducing as little air as possible during reconstitution. NOTE: If sodium pertechnetate Tc 99m injection must be diluted, use only Low Dissolved Oxygen (LDO) Secure the lead shield cover. Swirl the vial gently to mix contents and let stand for 15 minutes. Add 1 ml Acetate buffer at this time. (This will interfere with the tagging process if introduced any earlier). Buffer must be added (May be added up to 1 hour after Tc 99m) Examine vial contents; if the solution is not clear and free of particulate matter and discoloration on visual inspection, it should not be used Measure the radioactivity by a suitable calibration system and record prior to patient administration Buffered material should be used within 2 hours Appropriate quality control is recommended
Tagging Tips
If you need only a one or two mCi dose for your patient, use about 10 mCi of Tc 99m for your kit. Do not stretch your kit to 40 mCi if you do not need to. We have tested the kits to 40 mCi with a Friday generator eluted on Monday but recommend using only what you need Keep your volumes low. Take your Tc 99m and dilute to about 1cc with the Low Dissolved Oxygen saline and inject into the DMSA kit Let the kit stand for about 15 minutes with just the Tc 99m and DMSA (NO BUFFER) After 15 minutes, then add the buffer. This is only for patient comfort and will interfere with the tagging process if introduced any earlier After buffering you can add additional “Low Dissolved Oxygen” saline to dilute the kit You should inject the dose within 2 hours after making the kit for best results
Storage and Handling

Store the kit at 2°-8°C (36°-46°F) and protect from light
Sulfur Colloid

Sulfur Colloid

Preparation of Technetium Tc 99m-Sulfur Colloid:
Collect components: 10 ml. Reaction Vial, Solution A, Solution B, Lead Pig, Boiling Water Bath. Draw up 1 ml. Solution A. (HCl solution) in syringe. Draw up 2.5 ml. Tc-99m Pertechnetate containing desired activity, dilute with sterile normal saline if necessary. Add the 2.5 ml Tc-99m Pertechnetate to the shielded reaction vial. Immediately add the 1 ml. Solution A. Vent vial to release excess vacuum. Remove vent before boiling. Shake gently to mix. Place shielded vial in boiling water bath for 5 minutes for liver imaging and 3 minutes for lymphoscintigraphy imaging use. Remove from boiling water and let cool for a few minutes. Draw up 1 ml. Solution B. (Phosphate Buffer) while reaction vial is cooling After cooling Reaction vial, add the 1 ml Solution B and shake gently to mix. Caution: be sure vial is cool to avoid excess pressure Quality control: ITLC-SG in normal saline. Greater than 95% should stay at the origin Tc 99m Sulfur Colloid expires 6 hours after mixing

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Anazaohealth Corporation Drugs