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DosageHorses:Intravenous — 0.5 mL/100 lb body weight (0.5 mg/lb or 1.1 mg/kg).Intramuscular — 1.0 mL/100 lb body weight (1 mg/lb or 2.2 mg/kg).Cervidae:Administer intramuscularly, by either hand syringe or syringe dart, in the heavy muscles of the croup or shoulder.Fallow Deer (Dama dama) — 2.0 to 4.0 mL/100 lbs body weight (2.0 to 4.0 mg/lb or 4.4 to 8.8 mg/kg).Mule Deer (Odocoileus hemionus) — 1.0 to 2.0 mL/100 lbs body weight (1.0 to 2.0 mg/lb or 2.2 to 4.4 mg/kg).Sika Deer (Cervus nippon) — 1.0 to 2.0 mL/100 lbs body weight (1.0 to 2.0 mg/lb or 2.2 to 4.4 mg/kg).White-Tailed Deer (Odocoileus virginianus) — 1.0 to 2.0 mL/100 lbs body weight (1.0 to 2.0 mg/lb or 2.2 to 4.4 mg/kg).Elk (Cervus canadensis) — 0.25 to 0.5 mL/100 lbs body weight (0.25 to 0.5 mg/lb or 0.55 to 1.1 mg/kg).Following injection of xylazine, the animal should be allowed to rest quietly until the full effect has been reached.These dosages produce sedation which is usually maintained for 1 to 2 hours, and analgesia which lasts for 15 to 30 minutes. Preanesthetic to Local AnesthesiaXylazine at the recommended dosages can be used in conjunction with local anesthetics, such as procaine or lidocaine. Preanesthetic to General Anesthesia Xylazine at the recommended dosage rates produces an additive effect to central nervous system depressants such as pentobarbital sodium, thiopental sodium and thiamylal sodium. Therefore, the dosage of such compounds should be reduced and administered to the desired effect. In general, only 1/3 to 1/2 of the calculated dosage of the barbiturates will be needed to produce a surgical plane of anesthesia. Post-anesthetic or emergence excitement has not been observed in animals preanesthetized with xylazine.
Xylazine has been used successfully as a preanesthetic agent for pentobarbital sodium, thiopental sodium, thiamylal sodium, nitrous oxide, ether, halothane, glyceryl guaiacolate and methoxyflurane anesthesia.
Ketamine hydrochloride is well tolerated by cats and subhuman primates when administered by intramuscular injection.
Fasting prior to induction of anesthesia or restraint with ketamine hydrochloride is not essential; however, when preparing for elective surgery, it is advisable to withhold food for at least six hours prior to administration of ketamine hydrochloride.
Anesthesia may be of shorter duration in immature cats. Restraint in subhuman primate neonates (less than 24 hours of age) is difficult to achieve.
As with other anesthetic agents, the individual response to ketamine hydrochloride is somewhat varied depending upon the dose, general condition, and age of the subject so that dosage recommendations cannot be absolutely fixed.
The TolazilTM dose is 4.0 mg/kg body weight or 1.8 mg/lb (4 mL/100 kg or 4 mL/220 lb) to reverse the sedative effects of xylazine. The carefully calculated dose of TolazilTM should be given slowly by intravenous injection. Administration rate should approximate 1 mL/second.1,5
The table demonstrates the correct injection volume based on body weight:Body Weight (kg) Body Weight (lb) TolazilTM Injection Volume 250 kg 550 lb 10 mL 500 kg 1100 lb 20 mL
FOR SWINE, CALVES AND TURKEYS: 2.52 oz. (two scoops) dissolved in 500 mL (approximately 17 fl. oz.) of warm water will provide a stock solution of 100 mg of tetracycline hydrochloride activity per mL.
FOR TURKEYS ONLY: This stock solution when metered at approximately 1 oz. per gallon will provide drinking water containing 2,957 mg of tetracycline hydrochloride activity per gallon.
The contents of two scoops are sufficient to deliver the recommended daily dosage levels as follows:
At 25 mg/lb of body weight .... 2,040 total lbs of turkeys to be medicated.
At 10 mg/lb of body weight .... 5,100 total lbs of swine or calves to be mediciated.
Individual calf treatment ........ 5 mL (1 measuring teaspoonful) twice daily for each 100 lbs of body weight administered as a drench or by dose syringe.
FOR CHICKENS AND TURKEYS: To arrive at the recommended dosages, use the contents of 2 scoops to prepare stock solutions as follows:
200 mg/gallon - dissolve 2 scoops (2.52 oz.) in 7,570 mL warm water (2 gallons)
400 mg/gallon - dissolve 2 scoops (2.52 oz.) in 3,785 mL warm water (1 gallon)
800 mg/gallon - dissolve 2 scoops (2.52 oz.) in 1,892 mL warm water (0.5 gallon)
These stock solutions should then be metered into drinking water at approximately 1 oz. per gallon.
At 200-800 mg/gallon two scoops will provide 63.8 to 255 gallons of medicated drinking water.
SPECIAL DIRECTIONS FOR BABY CALVES AND BABY PIGS:
Administer this product one hour before or two hours after feeding milk or milk replacers. Provide clean (unmedicated) drinking water at all times.
NOTE: When using a watering trough, this product is to be administered twice a day in the drinking water of swine, calves and poultry. One-half of the recommended daily dosage level of antibiotic is to be consumed during each administration period, thus providing the drug in divided doses. The contents of this container (5 lb) will provide sufficient drug to treat 162,000 total pounds of swine or calves for a single day at the recommended dosage level of 10 mg/lb of body weight in divided doses. Or the contents of this container will treat 64,800 lbs of turkeys when supplied at 25 mg/lb or at 200-800 mg/gallon will provide 2,025 to 8,100 gallons of medicated drinking water for chickens or turkeys.
There is currently no dosage information available for this product. We apologize for any inconvenience.
DOSAGE: The dosage for cattle, sheep, swine, and horses is 3000 units per pound of bodyweight, or 1.0 mL for each 100 pounds of bodyweight, once daily. Treatment should not exceed 7 days in non-lactating dairy and beef cattle, sheep, and swine, or 5 days in lactating dairy cattle. If no improvement is observed within 48 hours, consult your veterinarian.
DOSAGE AND ADMINISTRATION: SulfaMedTM Injection 40% must be administered only by the intravenous route in cattle. Cattle should receive 1 mL of SulfaMedTM Injection 40% per 16 lb of body weight (55 mg/kg) as an initial dose, followed by 0.5 mL per 16 lb of body weight (27.5 mg/kg) every 24 hours thereafter. Sulfadimethoxine Boluses may be utilized for maintenance therapy in cattle. Representative weights and doses are indicated in the following table:
Each mL contains 400 mg sulfadimethoxine
Animal Weight Initial Dose Subsequent Daily Doses
25 mg/lb (55 mg/lg) 12.5 mg/lb (27.5 mg/kg)
250 lb (113.6 kg) 15.6 mL 7.8 mL
500 lb (227.2 kg) 31.2 mL 15.6 mL
750 lb (340.9 kg) 46.9 mL 23.5 mL
1000 lb (454.5 kg) 62.5 mL 31.3 mL
Length of treatment depends on the clinical response. In most cases treatment for 3 - 5 days is adequate. Treatment should be continued until the animal is asymptomatic for 48 hours.
DIRECTIONS FOR INTRAVENOUSE INJECTION:
1. A nose lead and/or halter sufficiently strong enough to effectively restrain or hold the animal's head steady so that the intravenous injection can be made with ease.
2. Hypodermic needles, 16 or 18 gauge and 2 inches long. Only new, sharp and sterile hypodermic needles should be used. Dull needles should be discarded. Extra needles should always be available in case the needle being used should become clogged.
3. Hypodermic syringes, 40- or 50-mL sterile, disposable or resusable glass syringes should be available.
4. Alcohol (70%) or equally effective antiseptic for disinfecting the skin.
Preparation of equipment: Glass syringes and regular hypodermic needles should be thoroughly cleaned and washed. Following this, the needles and syringes should be immersed in boiling water for 30 minutes prior to each injection. Regular hypodermic needles should not be used more than 3-4 times as repeated skin puncturing and boiling of the needles casues them to become quite dull. Disposable hypodermic needles and syringes should not be used more than once.
Restraint of animals: The cow should preferable be in a stancion for maximum restraint. If this is not possible, the animal should be restrained in a manner to prevent excessive movement. A nose lead should be applied and the animal's head turned sidewise to stretch the skin and tense the muscles of the neck region (See Figure 1).
Locating the jugular vein: Once the animal has been restrained (as above), you will notice a long depression of the skin from below the angle of the jaw to just above the shoulder. This is known as the jugular furrow or jugular groove. The jugular vein is located just under the jugular groove (See Figure 1).
Preparation of SulfaMedTM Injection 40% for injection: The rubber cap of the bottle should be thoroughly cleaned with 70% alcohol or other satisfactory antiseptic. The correct amount of SulfaMedTM of SulfaMedTM injection 40% for treatment should be calculated (see dosage directions) and that amount withdrawn into a syringe (See Figure 2). One or two syringefuls of air should be injected into the bottle first to make withdrawing the drug easier. SulfaMedTM Injection 40% should preferably be at room temperature when filling syringes and when injecting intravenously.
Entering the vein: The skin of the injection area should be clean and free of dirt. Cotton saturated with 70% alcohol (or suitable antiseptic) should be used to wipe the injection site. Apply pressure over the jugular vein close to the shoulder. This will reduce the flow of blood to the heart and cause jugular vein to bulge or enlarge (See Figure 3). When the jugular vein has been "raised", insert the hypodermic needle at a 45° angle through the skin just underneath the jugular vein. The beveled edge of the hypodermic needle should be up (See Figure 4).
After the skin has been punctured, the point of the needle should be directed toward the side of the vein and pushed into the center of the vein (See Figure 5). When the needle is in the center of the vein, there will be free flow of blood back through the needle. Release external pressure when you are sure the needle is within the vein.
Injection the SulfaMedTM Injection 40%: After the needle has been accurately inserted into the jugular vein, firmly attach the syringe containing SulfaMedTM Injection 40% to the inserted hypodermic needle. Caution, be sure syringe is free of air. Exert firm pressure on the plunger of the syringe to inject the SulfaMedTM Injection 40% while the barrel is held firmly. The injection should be made moderately slow - never rapidly. If the animal moves, causing resistance in pushing the plunger of the syringe, or if a bubble of the drug is noted under the skin, the needles is no longer within the vein. The needle should be repositioned.
When the injection is completed, quickly withdraw the syringe and needle with a quick pull and apply light pressure over the injection site with alcohol and cotton to minimize bleeding from the puncture site.
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